dimethyl 2-(ethylamino)-1,3-thiazole-4,5-dicarboxylate | 60716-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: dimethyl 2-(ethylamino)-1,3-thiazole-4,5-dicarboxylate
• 英文别名: 2-Ethylamino-4,5-dicarbomethoxy-thiazol；2-ethylamino-thiazole-4,5-dicarboxylic acid dimethyl ester
• CAS: 60716-99-6
• 化学式: C₉H₁₂N₂O₄S
• 分子量: 244.271
• InChiKey: RBMCBYIVWPGAQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-Imino-3-methyl-4-aethyl-1,2,4-thiodiazolin 、 丁炔二酸二甲酯 以 四氢呋喃 为溶剂， 生成 dimethyl 2-(ethylamino)-1,3-thiazole-4,5-dicarboxylate
  参考文献：
  名称：

  Cycloaddition-elimination reactions of iminothiadiazolines with acetylenes: hypervalent sulfur intermediates

  摘要：

  DOI：

  10.1016/s0040-4039(00)92950-2

文献信息

• ZnO-NR as the efficient catalyst for the synthesis of new thiazole and cyclopentadienone phosphonate derivatives in water
  作者：Zinatossadat Hossaini、Daryoush Zareyee、Fatemeh Sheikholeslami-Farahani、Samaneh Vaseghi、Afshin Zamani

  DOI：10.1002/hc.21362

  日期：2017.3

  AbstractFunctionalized thiazoles are generated from the reaction of dimethyl acetylenedicarboxylate, benzoylisothiocyanates, and primary amines and trialkyl phosphite in the presence of ZnO‐nanorods as the catalyst in water. Also, a series of polysubstituted cyclopentadienone phosphonate derivatives were synthesized via one‐pot multicomponent reactions of primary amines and phosphites with activated acetylenic compounds in water as the solvent at room temperature. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time, and straightforward procedure.
• AKIBA K.; TSUCHIYA T.; INAMOTO N., TETRAHEDRON LETT. <TELE-AY>, 1976, NO 22, 1877-1878.
  作者：AKIBA K.、 TSUCHIYA T.、 INAMOTO N.

  DOI：——

  日期：——