(E)-1-(pyridin-2-yl)-3-(pyridin-4-yl)prop-2-en-1-one | 18461-22-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-1-(pyridin-2-yl)-3-(pyridin-4-yl)prop-2-en-1-one
• 英文别名: 1-pyridin-2-yl-3-pyridin-4-yl-propenone；(E)-1-(2-Pyridyl)-3-(4-pyridyl)-2-propen-1-one；(E)-1-pyridin-2-yl-3-pyridin-4-ylprop-2-en-1-one
• CAS: 18461-22-8
• 化学式: C₁₃H₁₀N₂O
• mdl: MFCD22002367
• 分子量: 210.235
• InChiKey: XJFNJLLLKFTRCO-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-1-(pyridin-2-yl)-3-(pyridin-4-yl)prop-2-en-1-one 、 邻苯二胺 以40%的产率得到
  参考文献：
  名称：

  SAMULA K.; JURKOWSKA-KOWALCZYK E., ROCZ. CHEM. , 1974, 48, NO 12, 2287-2292

  摘要：

  DOI：

文献信息

• Phosphonate-functionalized heteroleptic ruthenium(II) bis(2,2′:6′,2″-terpyridine) complexes
  作者：Edwin C. Constable、Catherine E. Housecroft、Markéta Šmídková、Jennifer A. Zampese

  DOI：10.1139/cjc-2014-0065

  日期：2014.8

  The heteroleptic complexes [Ru(1)(4)][PF6]2, [Ru(2)(4)][PF6]2, [Ru(Phtpy)(4)][PF6]2, and [Ru(pytpy)(4)][PF6]2 (Phtpy = 4′-phenyl-2,2′:6′,2″-terpyridine, pytpy = 4′-(4-pyridyl)-2,2′:6′,2″-terpyridine, 1 and 2 = 4-methyl ester substituted derivatives of Phtpy and pytpy, 4 = ethyl 2,2′:6′,2″-terpyridine-4′-phosphonate) have been prepared. The single crystal structure of ligand 1 (1 = methyl 4-carboxy-4′-phenyl-2

  杂配配合物 [Ru(1)(4)][PF6]2、[Ru(2)(4)][PF6]2、[Ru(Phtpy)(4)][PF6]2 和 [Ru(pytpy) )(4)][PF6]2 (Phtpy = 4'-phenyl-2,2':6',2"-terpyridine, pytpy = 4'-(4-pyridyl)-2,2':6',2已经制备了“-三联吡啶，1和2=Phtpy和pytpy的4-甲基酯取代衍生物，4=2,2':6',2”-三联吡啶-4'-膦酸乙酯）。报道了配体 1 (1 = 甲基 4-羧基-4'-苯基-2,2':6',2"-三联吡啶)的单晶结构。4-甲基酯基团的引入导致钌 (II) 配合物的 MLCT 带发生小红移，并导致 Ru2+/Ru3+ 对向更正电位的小移。新配合物应作为开发适用于 p 型半导体敏化的钌 (II) 染料的有用起点。
• PHARMACEUTICAL USE OF TERPYRIDINE DERIVATIVE
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0677293A1

  公开（公告）日：1995-10-18

  A terpyridine derivative represented by general formula (I) (wherein R represents hydrogen, (un)substituted phenyl, pyridyl, etc.), which has the effect of promoting the production of nerve growth factors or a neurotrophic factor activity. Hence it can be used as an ameliorant or remedy for the symptoms and diseases accompanying peripheral nerve degeneration which is idiopathic or caused by trauma, chemicals such as alcohol or anticancer drug, inflammation, or metabolism as observed in, for example, diabetes. In addition, it can be used as an ameliorant or remedy for the symptoms and diseases accompanying central nerve degeneration, such as senile dementia of Alzheimer type, cerebrovascular dementia, Down's syndrome, Parkinson's disease or Hantington's chorea, mental and motor function incompetences caused by cerebral ischemia, cerebral infarction, cerebral hemorrhage or head injury, spinal neuroparalysis, and so forth.

  一种由通式(I)代表的terpyridine衍生物（其中R代表氢、（未）取代的苯基、吡啶基等），具有促进神经生长因子或神经营养因子活性产生的作用。因此，它可作为一种改善剂或治疗剂，用于治疗特发性或由创伤、化学物质（如酒精或抗癌药物）、炎症或代谢（如糖尿病）引起的伴随周围神经变性的症状和疾病。此外，它还可用于改善或治疗中枢神经退化引起的症状和疾病，如阿尔茨海默型老年痴呆、脑血管性痴呆、唐氏综合征、帕金森病或汉廷顿舞蹈症、脑缺血、脑梗塞、脑出血或头部损伤引起的精神和运动功能障碍、脊髓神经麻痹等。
• Supramolecular Assemblies of a Bis(terpyridine) Ligand and of its [2×2] Grid-type ZnII and CoII Complexes on Highly Ordered Pyrolytic Graphite
  作者：Ulrich Ziener、Jean-Marie Lehn、Ahmed Mourran、Martin Möller

  DOI：10.1002/1521-3765(20020215)8:4<951::aid-chem951>3.0.co;2-9

  日期：2002.2.15

  The synthesis and characterisation of bis(terpyridine)-derived ligands which are capable of forming [2 x 2] grid-like complexes is presented. Additional pyridine substituents on these ligands do not interfere with the complexation process. Adsorbing one of the pure ligands on highly ordered pyrolytic graphite (HOPG) shows a highly ordered structure stabilised by additional weak intermolecular C-H... N hydrogen bonds partially through the extra-pyridines as could be shown by scanning tunneling microscopy (STM) investigations. Similar adsorption experiments with one of the corresponding [2 x 2] Co-11 grid- type complexes on graphite, led also to a well-organised structure with interdigitation of the extra-pyridine moieties.