5-Methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.36
• InChiKey: RKYFKXLMWVUYJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  51.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  fumagillol 生成 5-Methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one
  参考文献：
  名称：

  GOTO, TOSIO;TANAKA, XIROKADZU;OKUXARA, MASAKUNI;XASIMOTO, MAKOTOSI

  摘要：

  DOI：

文献信息

• Methods of treating an overweight subject
  申请人：Zafgen, Inc.

  公开号：US10406134B2

  公开（公告）日：2019-09-10

  The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.

  本发明总体上部分涉及对有需要的患者进行减肥和/或改善葡萄糖耐量的方法，包括给药 MetAP2 抑制剂。
• METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT
  申请人：Vath James

  公开号：US20100016425A1

  公开（公告）日：2010-01-21

  The invention herein generally relates to pharmaceutical formulations and methods of treating an overweight or obese subject, and overweight- or obesity-related conditions.
• Methods of Treating an Overweight or Obese Subject
  申请人：Hughes Thomas E.

  公开号：US20120034233A1

  公开（公告）日：2012-02-09

  The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
• METHODS OF TREATING AN OVERWEIGHT SUBJECT
  申请人：Hughes Thomas E.

  公开号：US20130266578A1

  公开（公告）日：2013-10-10

  The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
• US8367721B2
  申请人：——

  公开号：US8367721B2

  公开（公告）日：2013-02-05