(1R,2R,4S)-1,4,5,6-Tetrabromo-7,7-dimethoxy-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester | 517876-68-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,2R,4S)-1,4,5,6-Tetrabromo-7,7-dimethoxy-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester
• 英文别名: methyl (1R,2R,4S)-1,4,5,6-tetrabromo-7,7-dimethoxybicyclo[2.2.1]hept-5-ene-2-carboxylate
• CAS: 517876-68-5
• 化学式: C₁₁H₁₂Br₄O₄
• 分子量: 527.83
• InChiKey: SGGKMRWYRZIQLL-PDFZIDOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1R,2R,4S)-1,4,5,6-Tetrabromo-7,7-dimethoxy-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 4.0h， 生成 ((1R,2R,4S)-1,4,5,6-Tetrabromo-7,7-dimethoxy-bicyclo[2.2.1]hept-5-en-2-yl)-methanol
  参考文献：
  名称：

  摘要：

  Effect of the conditions on the enantiomeric purity, overall yield, and isomeric composition of chiral polybromonorbornene Diels-Alder adducts of polybromocyclopentadienes and (-)-menthyl acrylate was studied. Enantiomerically pure polybromonorbornenecarboxylic acids were obtained by resolution of the corresponding racemates through diastereoisomeric salts with l-ephedrine. The structure of the products was confirmed by the IR and H-1 NMR spectra.

  DOI：

  10.1023/a:1015386221273
• 作为产物：
  描述：

  (-)-menthyl 1,2,3,4-tetrabromo-7,7-dimethoxybicyclo[2.2.1]hept-2-ene-5-carboxylate 在 氢氧化钾 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 2.5h， 生成 (1R,2R,4S)-1,4,5,6-Tetrabromo-7,7-dimethoxy-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester
  参考文献：
  名称：

  摘要：

  Effect of the conditions on the enantiomeric purity, overall yield, and isomeric composition of chiral polybromonorbornene Diels-Alder adducts of polybromocyclopentadienes and (-)-menthyl acrylate was studied. Enantiomerically pure polybromonorbornenecarboxylic acids were obtained by resolution of the corresponding racemates through diastereoisomeric salts with l-ephedrine. The structure of the products was confirmed by the IR and H-1 NMR spectra.

  DOI：

  10.1023/a:1015386221273

文献信息

• MUSTAFAEV, A. M.;IMAMALIEV, A. B.;GUSEJNOV, M. M., ZH. ORGAN. XIMII, 25,(1989) N, S. 1908-1915
  作者：MUSTAFAEV, A. M.、IMAMALIEV, A. B.、GUSEJNOV, M. M.

  DOI：——

  日期：——
• ——
  作者：E. G. Mamedov

  DOI：10.1023/a:1015386221273

  日期：——

  Effect of the conditions on the enantiomeric purity, overall yield, and isomeric composition of chiral polybromonorbornene Diels-Alder adducts of polybromocyclopentadienes and (-)-menthyl acrylate was studied. Enantiomerically pure polybromonorbornenecarboxylic acids were obtained by resolution of the corresponding racemates through diastereoisomeric salts with l-ephedrine. The structure of the products was confirmed by the IR and H-1 NMR spectra.