2-Oxazolepropanoic acid, 5-(4-hydroxyphenyl)-4-phenyl- | 90044-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Oxazolepropanoic acid, 5-(4-hydroxyphenyl)-4-phenyl-
• 英文别名: 3-[5-(4-hydroxyphenyl)-4-phenyl-1,3-oxazol-2-yl]propanoic acid
• CAS: 90044-49-8
• 化学式: C₁₈H₁₅NO₄
• 分子量: 309.3
• InChiKey: YAISBCRKKPIEOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(4-methoxyphenyl)-4-phenyl-2-oxazolepropanoic acid 、 三溴化硼 、 、 水 在 乙醚 、 水 、 sodium hydroxide 、 Brine 、 magnesium sulfate 、 silica gel 、 CH2Cl2 EtOAc AcOH 、 乙酸乙酯 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以9.0 Grams of the title and major product were obtained which的产率得到2-Oxazolepropanoic acid, 5-(4-hydroxyphenyl)-4-phenyl-
  参考文献：
  名称：

  Hydroxy substituted 4,5-diphenyl-2-oxazole propanoic acid

  摘要：

  本发明揭示了5-(4-羟基苯基)-4-苯基-2-噁唑丙酸，4-(4-羟基苯基)-5-苯基-2-噁唑丙酸及其药学上可接受的盐作为抗炎药物，其制药组合物和使用方法。

  公开号：

  US04659728A1

文献信息

• Oxaprozin or closely related compound for the treatment and prevention of pruritus
  申请人：Astion Development A/S

  公开号：EP1707199A1

  公开（公告）日：2006-10-04

  The invention provides methods and medicaments for the treatment of pruritus in general or pruritus caused by or associated with dermatological diseases including the treatment of the underlying disease by topically administering to skin or by systemically administering to a subject Oxaprozin or a closely related compound or a salt thereof.

  本发明提供了治疗瘙痒症的方法和药物，包括治疗与皮肤病相关的瘙痒症，通过局部给药或全身给药氧氯氮或其密切相关化合物或其盐来治疗基础疾病。
• Selective Cox-2 Inhibitors
  申请人：Cali M. Brian

  公开号：US20070293542A1

  公开（公告）日：2007-12-20

  The invention features compounds that are inhibitors of COX-2 activity. Certain of the compounds are inhibitors of FAAH activity as well as COX-2 activity. The compounds include a 5-membered or 6-membered substituted or unsubstituted heteroaryl or heterocyclyl ring having one or two heteroatoms selected from the group consisting of O, S, and N that is linked to two substituted or unsubstituted 6-membered aryl or heteroaryl groups that can be the same or different.

  这项发明涉及一种抑制COX-2活性的化合物。其中一些化合物不仅是COX-2活性的抑制剂，还是FAAH活性的抑制剂。这些化合物包括一个带有一个或两个O、S或N杂原子的5元或6元取代或未取代的杂芳基或杂环基环，该环连接两个取代或未取代的6元芳基或杂芳基基团，这两个基团可以相同也可以不同。
• Dermatological compositions comprising oxaprozin or a closely related compound for the treatment of dermatological diseases
  申请人：Astion Development A/S

  公开号：EP1707200A1

  公开（公告）日：2006-10-04

  The invention relates to dermatological compositions of Oxaprozin or a closely related compound suitable adapted for the treatment of a dermatological disease, where at least two of the enzymes selected from protein tyrosine kinase Syk, protein tyrosine kinase ZAP-70 and phosphodiesterase IV play a role in mediating the dermatological disease. The invention also encompasses dermatological compositions for the treatment of pruritus.

  本发明涉及奥沙普秦或密切相关化合物的皮肤病组合物，适用于治疗皮肤病，其中至少两种酶选自蛋白酪氨酸激酶Syk、蛋白酪氨酸激酶ZAP-70和磷酸二酯酶IV，它们在介导皮肤病中发挥作用。本发明还包括用于治疗瘙痒症的皮肤病组合物。
• Oxaprozin or a closely related compound for the treatment of eczema
  申请人：Astion Development A/S

  公开号：EP1707201A1

  公开（公告）日：2006-10-04

  The present invention relates to a novel principle of treating dermatological diseases comprising inhibiting several crucial steps in the inflammatory cascade including at least the inhibition of one or more of the enzymes Protein tyrosine kinase Syk, Protein tyrosine kinase ZAP-70 and phosphodiesterase IV (PDE-IV). The invention provides medicaments and methods for the treatment of inflammatory dermatological diseases, particularly eczemas, comprising Oxaprozin or a closely related compound or a salt thereof.

  本发明涉及一种治疗皮肤病的新原理，包括抑制炎症级联反应中的几个关键步骤，至少包括抑制一种或多种酶蛋白酪氨酸激酶Syk、蛋白酪氨酸激酶ZAP-70和磷酸二酯酶IV（PDE-IV）。本发明提供了治疗炎症性皮肤病，特别是湿疹的药物和方法，其中包含 Oxaprozin 或一种密切相关的化合物或其盐。
• Dermatological compositions and salts for the treatment of dermatological diseases
  申请人：Weidner Sloth Morten

  公开号：US20060222671A1

  公开（公告）日：2006-10-05

  The invention relates to dermatological compositions of Oxaprozin or a closely related compound suitable adapted for the treatment of a dermatological disease, where at least two of the enzymes selected from protein tyrosine kinase Syk, protein tyrosine kinase ZAP-70 and phosphodiesterase IV play a role in mediating the dermatological disease. The invention also encompasses dermatological compositions for the treatment of pruritus.

  本发明涉及奥沙普秦或密切相关化合物的皮肤病组合物，适用于治疗皮肤病，其中至少两种酶选自蛋白酪氨酸激酶Syk、蛋白酪氨酸激酶ZAP-70和磷酸二酯酶IV，它们在介导皮肤病中发挥作用。本发明还包括用于治疗瘙痒症的皮肤病组合物。