3-pyridin-4-yl-benzophenone | 339333-76-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-pyridin-4-yl-benzophenone
• 英文别名: 1-[3-(4-Pyridyl)phenyl]ethanone；1-[3-(Pyridin-4-yl)phenyl]ethan-1-one；1-(3-pyridin-4-ylphenyl)ethanone
• CAS: 339333-76-5
• 化学式: C₁₃H₁₁NO
• mdl: MFCD12785846
• 分子量: 197.236
• InChiKey: ZLJWVMPGPJLLBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P330,P363,P501
• 危险性描述：
  H302,H312,H332

反应信息

• 作为产物：
  描述：

  methyl 4-(3-acetylphenyl)-4H-pyridine-1-carboxylate 在 氧气 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 生成 3-pyridin-4-yl-benzophenone
  参考文献：
  名称：

  通过电化学制备的有机锌试剂合成功能化的4-苯基吡啶

  摘要：

  描述了各种官能化的4-苯基吡啶2的有效和方便的合成。该过程的关键步骤是芳族有机锌试剂1的电化学形成及其与吡啶鎓盐的偶联。在温和的条件下将中间体1,4-二氢吡啶氧化，以中等至较高的总收率提供官能化的4-苯基吡啶。

  DOI：

  10.1016/s0040-4020(01)00015-1

文献信息

• 4-SUBSTITUTED-2-THIAZOLE AMIDES AS ANTIVIRAL AGENTS
  申请人：Southern Research Institute

  公开号：US20200399264A1

  公开（公告）日：2020-12-24

  The present disclosure is concerned with benzoannulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, Eastern equine encephalitis, Western equine encephalitis, dengue, West Nile, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制病毒感染的苯并环己烯化合物，以及利用这些化合物治疗病毒感染的方法，例如印度支那病毒、委内瑞拉马脑炎、东部马脑炎、西部马脑炎、登革热、西尼罗河病毒、流感和寨卡病毒。本摘要旨在作为特定领域搜索的扫描工具，并不意味着限制本发明。
• INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20160145251A1

  公开（公告）日：2016-05-26

  Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

  本文披露了抑制由肌动蛋白相关转录因子和血清反应因子或肌动蛋白相关转录因子和血清反应因子（“MRTF / SRF”）介导的基因转录的抑制剂，以及它们在治疗或预防癌症和纤维化方面的使用方法。特别地，本文披露了公式（I）和公式（II）的化合物及其药学上可接受的盐：其中取代基如所述。
• [EN] INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME<br/>[FR] INHIBITEURS DE LA TRANSCRIPTION DE GÈNES MÉDIÉE PAR LE FACTEUR APPARENTÉ À LA MYOCARDINE ET LE FACTEUR DE RÉPONSE SÉRIQUE (MRTF/SRF) ET PROCÉDÉS POUR LES UTILISER
  申请人：UNIV MICHIGAN

  公开号：WO2016073847A2

  公开（公告）日：2016-05-12

  Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor ("MRTF/SRF"), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.