[(1S,2R,3S)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-2-methyl-hex-5-enyl]-carbamic acid benzyl ester | 269715-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1S,2R,3S)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-2-methyl-hex-5-enyl]-carbamic acid benzyl ester
• 英文别名: benzyl N-[(2S,3R,4S)-1-[tert-butyl(dimethyl)silyl]oxy-4-hydroxy-3-methylhept-6-en-2-yl]carbamate
• CAS: 269715-81-3
• 化学式: C₂₂H₃₇NO₄Si
• 分子量: 407.626
• InChiKey: CZGMVFWDKRZCSX-RLLQIKCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.88
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(1S,2R,3S)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-2-methyl-hex-5-enyl]-carbamic acid benzyl ester 在 palladium on activated charcoal 2,6-二甲基吡啶 、 氢气 、 对甲苯磺酸 、 臭氧 、 三乙胺 、 三苯基膦 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 苯 为溶剂， 生成 1-[(2R,4S,5R,6S)-4-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-methylpiperidin-2-yl]propan-2-one
  参考文献：
  名称：

  Stereoselective synthesis of a tricyclic guanidinium model of cylindrospermopsin

  摘要：

  An 11-step enantioselective synthesis of the A-ring of cylindrospermopsin is described using an intramolecular conjugate addition as the key step to forming the piperidine ring. Further elaboration generates a tricyclic guanidine via a sequential double displacement strategy as a model for the cylindrospermopsin guanidinium core. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02348-5
• 作为产物：
  描述：

  [(1S,2R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-2-methyl-propyl]-carbamic acid benzyl ester 在 三氟化硼乙醚 、 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 生成 [(1S,2R,3S)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-2-methyl-hex-5-enyl]-carbamic acid benzyl ester
  参考文献：
  名称：

  Stereoselective synthesis of a tricyclic guanidinium model of cylindrospermopsin

  摘要：

  An 11-step enantioselective synthesis of the A-ring of cylindrospermopsin is described using an intramolecular conjugate addition as the key step to forming the piperidine ring. Further elaboration generates a tricyclic guanidine via a sequential double displacement strategy as a model for the cylindrospermopsin guanidinium core. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02348-5