(R)-2-Trifluoromethanesulfonyloxy-succinic acid dimethyl ester | 171049-36-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (R)-2-Trifluoromethanesulfonyloxy-succinic acid dimethyl ester
• 英文别名: Dimethyl (r)-malate o-triflate；dimethyl (2R)-2-(trifluoromethylsulfonyloxy)butanedioate
• CAS: 171049-36-8
• 化学式: C₇H₉F₃O₇S
• 分子量: 294.205
• InChiKey: VTGAHMHUTNTATF-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  ((1S,3S)-3-Amino-2,2-dimethyl-cyclopropyl)-methanol 、 (R)-2-Trifluoromethanesulfonyloxy-succinic acid dimethyl ester 在 2,6-二甲基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-2-((1S,3S)-3-Hydroxymethyl-2,2-dimethyl-cyclopropylamino)-succinic acid dimethyl ester
  参考文献：
  名称：

  Design and synthesis of conformationally constrained, extended and reverse turn pseudopeptides as Grb2-SH2 domain antagonists

  摘要：

  A series of conformationally constrained and flexible pseudopeptide derivatives of the tripeptide pYVN were prepared as potential antagonists of interactions of phosphotyrosine peptides with the Grb2-SH2 domain. The conformation ally constrained compounds contained trans- and cis-cyclopropanes as replacements to enforce locally extended and reverse turn peptide conformations, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00013-3

文献信息

• Design and synthesis of conformationally constrained, extended and reverse turn pseudopeptides as Grb2-SH2 domain antagonists
  作者：Hilary R Plake、Thomas B Sundberg、Angela R Woodward、Stephen F Martin

  DOI：10.1016/s0040-4039(03)00013-3

  日期：2003.2

  A series of conformationally constrained and flexible pseudopeptide derivatives of the tripeptide pYVN were prepared as potential antagonists of interactions of phosphotyrosine peptides with the Grb2-SH2 domain. The conformation ally constrained compounds contained trans- and cis-cyclopropanes as replacements to enforce locally extended and reverse turn peptide conformations, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.