(S)-2-[3-((S)-2-{3-[(S)-2-(3-Benzyloxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carbonyl]-phenylcarbamoyl}-pyrrolidine-1-carbonyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | 259665-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-[3-((S)-2-{3-[(S)-2-(3-Benzyloxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carbonyl]-phenylcarbamoyl}-pyrrolidine-1-carbonyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl (2S)-2-[[3-[(2S)-2-[[3-[(2S)-2-[(3-phenylmethoxycarbonylphenyl)carbamoyl]pyrrolidine-1-carbonyl]phenyl]carbamoyl]pyrrolidine-1-carbonyl]phenyl]carbamoyl]pyrrolidine-1-carboxylate
• CAS: 259665-76-4
• 化学式: C₄₈H₅₂N₆O₉
• 分子量: 856.976
• InChiKey: ASBCJEJFQXRMIR-MXVPUGLGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  63
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  184
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (S)-2-[3-((S)-2-{3-[(S)-2-(3-Benzyloxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carbonyl]-phenylcarbamoyl}-pyrrolidine-1-carbonyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 在 palladium on activated charcoal 盐酸 、 氢气 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 6.0h， 生成 cyclo-[(L)-Pro-AB]3
  参考文献：
  名称：

  A New Cyclic Pseudopeptide Composed of (l)-Proline and 3-Aminobenzoic Acid Subunits as a Ditopic Receptor for the Simultaneous Complexation of Cations and Anions

  摘要：

  The synthesis and receptor properties of a cyclic pseudopeptide composed of (L)-proline and the nonnatural amino acid 3-aminobenzoic acid in an alternating sequence are described. The structure of cyclo[(L)Pro-AB](3) was determined in the solid state by X-ray crystallography and in solution by one- and two-dimensional NMR techniques and FT-IR spectroscopy. The cyclic peptide preferentially adopts conformations comparable with the cone conformation of calixarenes. Similar to calixarenes, cyclo[(L)Pro-AB](3) is able to bind cations by cation-pi interactions with its aromatic subunits. In some complexes, the peptide NH groups interact additionally with anions and the cyclic peptide thus behaves as a ditopic receptor. The structure of the ternary complex between cyclo[(L)Pro-AB](3) and N-methylquinuclidinium iodide was determined by X-ray crystallography. Spectroscopic investigations show that this complex has a similar geometry in solution. Stability constants of complexes of the cyclopeptide with various ion pairs have been determined. Crossover experiments show that electrostatic interactions between cation and anion complexed by cyclo[(L)Pro-AB](3) result in cooperative effects of either ion on the complexation of the corresponding counterion. The binding properties of cyclo[(L)Pro-AB](3) are correlated with its conformation in solution. The properties of related cyclic hexapeptides in which one or two (L)-proline subunits are replaced by (L)-glutamic acid are also described. In comparison with cyclo[(L)Pro-AB](3), these peptides possess a reduced cation and anion affinity. Anion complexation is weakened because the amide NH groups at the glutamic acid subunits are involved in strong intramolecular hydrogen bonds and are not available for interactions with other partners. Consequently, the cation complex stabilities also decrease. The amino acid subunits obviously influence the receptor properties of such cyclopeptides by controlling their solution conformation.

  DOI：

  10.1021/jo991087d
• 作为产物：
  描述：

  (S)-2-(3-Benzyloxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 在 palladium on activated charcoal 氢气 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 、 chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 (S)-2-[3-((S)-2-{3-[(S)-2-(3-Benzyloxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carbonyl]-phenylcarbamoyl}-pyrrolidine-1-carbonyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  A New Cyclic Pseudopeptide Composed of (l)-Proline and 3-Aminobenzoic Acid Subunits as a Ditopic Receptor for the Simultaneous Complexation of Cations and Anions

  摘要：

  The synthesis and receptor properties of a cyclic pseudopeptide composed of (L)-proline and the nonnatural amino acid 3-aminobenzoic acid in an alternating sequence are described. The structure of cyclo[(L)Pro-AB](3) was determined in the solid state by X-ray crystallography and in solution by one- and two-dimensional NMR techniques and FT-IR spectroscopy. The cyclic peptide preferentially adopts conformations comparable with the cone conformation of calixarenes. Similar to calixarenes, cyclo[(L)Pro-AB](3) is able to bind cations by cation-pi interactions with its aromatic subunits. In some complexes, the peptide NH groups interact additionally with anions and the cyclic peptide thus behaves as a ditopic receptor. The structure of the ternary complex between cyclo[(L)Pro-AB](3) and N-methylquinuclidinium iodide was determined by X-ray crystallography. Spectroscopic investigations show that this complex has a similar geometry in solution. Stability constants of complexes of the cyclopeptide with various ion pairs have been determined. Crossover experiments show that electrostatic interactions between cation and anion complexed by cyclo[(L)Pro-AB](3) result in cooperative effects of either ion on the complexation of the corresponding counterion. The binding properties of cyclo[(L)Pro-AB](3) are correlated with its conformation in solution. The properties of related cyclic hexapeptides in which one or two (L)-proline subunits are replaced by (L)-glutamic acid are also described. In comparison with cyclo[(L)Pro-AB](3), these peptides possess a reduced cation and anion affinity. Anion complexation is weakened because the amide NH groups at the glutamic acid subunits are involved in strong intramolecular hydrogen bonds and are not available for interactions with other partners. Consequently, the cation complex stabilities also decrease. The amino acid subunits obviously influence the receptor properties of such cyclopeptides by controlling their solution conformation.

  DOI：

  10.1021/jo991087d

文献信息

• A New Cyclic Pseudopeptide Composed of (<scp>l</scp>)-Proline and 3-Aminobenzoic Acid Subunits as a Ditopic Receptor for the Simultaneous Complexation of Cations and Anions
  作者：Stefan Kubik、Richard Goddard

  DOI：10.1021/jo991087d

  日期：1999.12.1

  The synthesis and receptor properties of a cyclic pseudopeptide composed of (L)-proline and the nonnatural amino acid 3-aminobenzoic acid in an alternating sequence are described. The structure of cyclo[(L)Pro-AB](3) was determined in the solid state by X-ray crystallography and in solution by one- and two-dimensional NMR techniques and FT-IR spectroscopy. The cyclic peptide preferentially adopts conformations comparable with the cone conformation of calixarenes. Similar to calixarenes, cyclo[(L)Pro-AB](3) is able to bind cations by cation-pi interactions with its aromatic subunits. In some complexes, the peptide NH groups interact additionally with anions and the cyclic peptide thus behaves as a ditopic receptor. The structure of the ternary complex between cyclo[(L)Pro-AB](3) and N-methylquinuclidinium iodide was determined by X-ray crystallography. Spectroscopic investigations show that this complex has a similar geometry in solution. Stability constants of complexes of the cyclopeptide with various ion pairs have been determined. Crossover experiments show that electrostatic interactions between cation and anion complexed by cyclo[(L)Pro-AB](3) result in cooperative effects of either ion on the complexation of the corresponding counterion. The binding properties of cyclo[(L)Pro-AB](3) are correlated with its conformation in solution. The properties of related cyclic hexapeptides in which one or two (L)-proline subunits are replaced by (L)-glutamic acid are also described. In comparison with cyclo[(L)Pro-AB](3), these peptides possess a reduced cation and anion affinity. Anion complexation is weakened because the amide NH groups at the glutamic acid subunits are involved in strong intramolecular hydrogen bonds and are not available for interactions with other partners. Consequently, the cation complex stabilities also decrease. The amino acid subunits obviously influence the receptor properties of such cyclopeptides by controlling their solution conformation.