1,5,9,13,17,21-hexathiacyclotetracosane-3,11,19-triol | 116912-58-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,5,9,13,17,21-hexathiacyclotetracosane-3,11,19-triol
• CAS: 116912-58-4
• 化学式: C₁₈H₃₆O₃S₆
• 分子量: 492.878
• InChiKey: QIENEYMINSOSNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  213
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  neodymium(III) chloride hexahydrate 、 1,5,9,13,17,21-hexathiacyclotetracosane-3,11,19-triol 以 甲醇 、 乙腈 为溶剂， 生成 {Nd(OH2)7(OHMe)2}Cl3
  参考文献：
  名称：

  Rogers, Robin D.; Rollins, Andrew N.; Henry, Rodger F., Inorganic Chemistry, 1991, vol. 30, # 26, p. 4946 - 4954

  摘要：

  DOI：

文献信息

• ANALOGS OF SALINOSPORAMIDE A
  申请人：Myers Andrew G.

  公开号：US20090054665A1

  公开（公告）日：2009-02-26

  Disclosed herein are analogs of Salinosporamide A, having the Formula I as follows: Like Salinosporamide A, the compounds of the present invention will inhibit the proteasome, an intracellular enzyme complex that destroys proteins the cell no longer needs. Without the proteasome, proteins would build up and clog cellular machinery. Fast-growing cancer cells make especially heavy use of the proteasome, so thwarting its action is a compelling drug strategy.

  本文披露了类似于盐链霉素A的类似物，其化学式为I，如下所示：与盐链霉素A一样，本发明的化合物将抑制蛋白酶体，一种细胞内酶复合物，用于分解细胞不再需要的蛋白质。没有蛋白酶体，蛋白质将积累并阻塞细胞机制。快速生长的癌细胞尤其大量利用蛋白酶体，因此阻碍其作用是一种引人注目的药物策略。
• New metallocene catalyst for olefin or styrene polymerization and polymerization method using the metallocene catalyst
  申请人：Samsung General Chemicals Co., Ltd.

  公开号：EP0964004A1

  公开（公告）日：1999-12-15

  The new metallocene catalysts according to the present invention are prepared by reacting a metallocene compound with a compound having at least two functional groups. The metallocene compound is a transition metal compound in which a transition metal is coordinated with a main ligand such as cycloalkanedienyl group and an ancillary ligand. The functional groups of the compound having at least two functional groups are selected from the group consisting of a hydroxy group, a thiol group, a primary amine group, a secondary amine group, etc. The metallocene catalysts according to the present invention have a structure in which an ancillary ligand of a metallocene compound is bonded with functional groups. A structure of the metallocene catalysts can be varied according to the metallocene compounds, the compound having at least two functional groups, and the molar ratio of each reactant. The metallocene catalyst is employed with a co-catalyst for styrene and olefin polymerization. The co-catalyst is an organometallic compound or a mixture of non-coordinated Lewis acid and alkylaluminium. The organometallic compound is usually alkylaluminoxane and organoaluminium compound. The syndiotactic polystyrenes and the polyolefins having good physical properties are prepared by using the metallocene catalyst according to the present invention. A monomer for polymerization includes styrene, derivatives of styrene, and a compound having ethylenically unsaturated double bonds. Those compounds are homopolymerized and copolymerized to give polystyrene and polyolefin.

  本发明的新型茂金属催化剂是通过茂金属化合物与至少具有两个官能团的化合物反应制备的。茂金属化合物是一种过渡金属化合物，其中过渡金属与主配体（如环烷二烯基）和辅助配体配位。具有至少两个官能团的化合物的官能团选自羟基、硫醇基、伯胺基、仲胺基等组成的组。根据本发明的茂金属催化剂具有茂金属化合物的辅助配体与官能团键合的结构。茂金属催化剂的结构可根据茂金属化合物、具有至少两个官能团的化合物以及各反应物的摩尔比而变化。茂金属催化剂与助催化剂一起用于苯乙烯和烯烃聚合。助催化剂是一种有机金属化合物或非配位路易斯酸和烷基铝的混合物。有机金属化合物通常是烷基铝氧烷和有机铝化合物。使用本发明的茂金属催化剂可以制备具有良好物理性能的辛二聚苯乙烯和聚烯烃。用于聚合的单体包括苯乙烯、苯乙烯衍生物和具有乙烯不饱和双键的化合物。这些化合物经过均聚和共聚可得到聚苯乙烯和聚烯烃。
• Metallocene catalysts for olefin polymerization and method of polymerizing olefins using the metallocene catalysts
  申请人：Samsung General Chemicals Co., Ltd.

  公开号：EP0994132A1

  公开（公告）日：2000-04-19

  The new metallocene catalysts according to the present invention are prepared by reacting a metallocene compound with a compound having at least two functional groups. The metallocene compound is a transition metal compound, which is coordinated with a main ligand such as cyclopentadienyl group, and an ancillary ligand. The functional groups in the compound are selected from the group consisting of a hydroxyl group, an alkyl or aryl magnesium halide, a thiol group, a primary amine group, a secondary amine group, a primary phosphorous group, a secondary phosphorous group, etc. The metallocene catalysts according to the present invention have a structure in which an ancillary ligand of a metallocene compound is bonded to the functional groups of a compound having at least two functional groups. A structure of the metallocene catalysts can be varied with the type of a metallocene compound and a compound having at least two functional groups, and the molar ratio of each reactant. The metallocene catalysts are employed with a co-catalyst for olefin polymerization. The co-catalyst is an organometallic compound, or a mixture of non-coordinated Lewis acid and alkylaluminium as it is well known in the art.

  本发明的新型茂金属催化剂是通过茂金属化合物与至少具有两个官能团的化合物反应制备的。茂金属化合物是一种过渡金属化合物，它与一种主配体（如环戊二烯基）和一种辅助配体配位。化合物中的官能团选自羟基、烷基或芳基卤化镁、硫醇基、伯胺基、仲胺基、伯磷基、仲磷基等。根据本发明的茂金属催化剂具有一种结构，其中茂金属化合物的辅助配体与具有至少两个官能团的化合物的官能团键合。茂金属催化剂的结构可以随茂金属化合物和至少具有两个官能团的化合物的类型以及各反应物的摩尔比而变化。茂金属催化剂与助催化剂一起用于烯烃聚合。助催化剂是一种有机金属化合物，或者是非配位路易斯酸和烷基铝的混合物，这在本领域是众所周知的。
• Metallocene catalysts for olefin polymerization and methog of polymerizing olefins using the metallocene catalysts
  申请人：Samsung General Chemicals Co., Ltd.

  公开号：EP2174963A2

  公开（公告）日：2010-04-14

  The new metallocene catalysts according to the present invention are prepared by reacting a metallocene compound with a compound having at least two functional groups. The metallocene compound is a transition metal compound, which is coordinated with a main ligand such as cyclopentadienyl group, and an ancillary ligand. The functional groups in the compound are selected from the group consisting of a hydroxyl group, an alkyl or aryl magnesium halide, a thiol group, a primary amine group, a secondary amine group, a primary phosphorous group, a secondary phosphorous group, etc. The metallocene catalysts according to the present invention have a structure in which an ancillary ligand of a metallocene compound is bonded to the functional groups of a compound having at least two functional groups. A structure of the metallocene catalysts can be varied with the type of a metallocene compound and a compound having at least two functional groups, and the molar ratio of each reactant. The metallocene catalysts are employed with a co-catalyst for olefin polymerization. The co-catalyst is an organometallic compound, or a mixture of non-coordinated Lewis acid and alkyl aluminium as it is well known in the art.

  本发明的新型茂金属催化剂是通过茂金属化合物与至少具有两个官能团的化合物反应制备的。茂金属化合物是一种过渡金属化合物，它与一种主配体（如环戊二烯基）和一种辅助配体配位。化合物中的官能团选自羟基、烷基或芳基卤化镁、硫醇基、伯胺基、仲胺基、伯磷基、仲磷基等组成的组。根据本发明的茂金属催化剂具有一种结构，其中茂金属化合物的辅助配体与具有至少两个官能团的化合物的官能团键合。茂金属催化剂的结构可以随茂金属化合物和至少具有两个官能团的化合物的类型以及各反应物的摩尔比而变化。茂金属催化剂与助催化剂一起用于烯烃聚合。助催化剂是一种有机金属化合物，或者是非配位路易斯酸和烷基铝的混合物，这在本领域是众所周知的。
• Image making medium
  申请人：——

  公开号：US20030035917A1

  公开（公告）日：2003-02-20

  The invention relates to an image support medium for creation of an aesthetic image that is an work or object for display. This support medium includes a polymer in an amount sufficient to enable the image to have at least one aesthetic element. In different embodiments, the image support medium is an image support stabilizer, the polymer is a synthetic absorbent or conductive polymer, or the polymer is a transparent or synthetic translucent polymer and a property of this transparent or translucent polymer is enhanced to facilitate the creation or preservation of the image by at least one stabilizer. The invention also relates to a method for preparing this image support medium. The method includes forming a reaction mixture comprising a monomer in an amount sufficient to provide or enable the image to have an aesthetic element, and processing the reaction mixture into a 2- or 3-dimensional shape.

  本发明涉及一种图像支持介质，用于创建作为作品或展示对象的美学图像。这种支撑介质包括一种聚合物，其用量足以使图像具有至少一种审美元素。在不同的实施例中，图像支持介质是一种图像支持稳定剂，聚合物是一种合成的吸收性或导电性聚合物，或者聚合物是一种透明或合成的半透明聚合物，并且这种透明或半透明聚合物的特性被至少一种稳定剂增强，以促进图像的创建或保存。本发明还涉及一种制备这种图像支持介质的方法。该方法包括形成由单体组成的反应混合物，其用量足以提供或使图像具有美学元素，并将反应混合物加工成 2 维或 3 维形状。