4'-(p-fluorobenzenesulfonate)-4-hydroxychalcone | 1010118-53-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4'-(p-fluorobenzenesulfonate)-4-hydroxychalcone
• 英文别名: [4-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]phenyl] 4-fluorobenzenesulfonate
• CAS: 1010118-53-2
• 化学式: C₂₁H₁₅FO₅S
• 分子量: 398.412
• InChiKey: NCZJLPOEQIDAFI-LZWSPWQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-acetylphenyl 4-fluorobenzenesulfonate 、 对羟基苯甲醛 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 4'-(p-fluorobenzenesulfonate)-4-hydroxychalcone
  参考文献：
  名称：

  磺酸查尔酮是新型的电压依赖性K +通道阻滞剂。

  摘要：

  合成了查尔酮衍生物1-17，并研究了它们的电压依赖性K +通道抑制活性。有效的K +通道阻滞剂显示为磺酸盐查耳酮9-17，其中磺酰氧基位于A环上。3'-（对氨基苯磺酰基羟基）-4-羟基查尔酮17（IC50 = 0.51 +/- 0.05 microM）是最有效的K +通道阻滞剂。

  DOI：

  10.1016/j.bmcl.2007.10.114

文献信息

• METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS
  申请人：PARK Ki Hun

  公开号：US20100068730A1

  公开（公告）日：2010-03-18

  The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.
• COMPOSITION FOR DIAGNOSING, TREATING, AND PREVENTING LIVER DISEASE
  申请人：Lee Jung Weon

  公开号：US20130178533A1

  公开（公告）日：2013-07-11

  The present invention relates to a composition for diagnosing, treating, and preventing liver disease, more particularly a composition for diagnosing liver disease comprising a material for measuring the grade of TM4SF5 (transmembrane 4 L six family member 5 or four-transmembrane L6 superfamily member 5) protein, a kit for diagnosing liver disease comprising the said composition, a method for providing information necessary for diagnosing liver disease composed of the following steps; measuring the level of TM4SF5 protein and the expressions and phosphorylations of TM4SF5 expression related signaling proteins; and comparing the measured levels with those of the normal control, a method for screening a material for treating liver disease, and a composition for treating or preventing liver disease comprising a material inhibiting TM4SF5 protein expression or the expressions and phosphorylations of TM4SF5 expression related signaling proteins.
• US8445722B2
  申请人：——

  公开号：US8445722B2

  公开（公告）日：2013-05-21
• US9057725B2
  申请人：——

  公开号：US9057725B2

  公开（公告）日：2015-06-16
• US9072698B2
  申请人：——

  公开号：US9072698B2

  公开（公告）日：2015-07-07