2-propyl-cyclooctanol | 100533-88-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-propyl-cyclooctanol
• 英文别名: 2-Propylcyclooctan-1-ol
• CAS: 100533-88-8
• 化学式: C₁₁H₂₂O
• 分子量: 170.295
• InChiKey: SUDKVMHBXKEDNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-propyl-cyclooctanol 生成 3,5-dinitro-benzoic acid-(2-propyl-cyclooctyl ester)
  参考文献：
  名称：

  Braude et al., Journal of the Chemical Society, 1957, p. 4711,4718

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 铂 作用下， 生成 2-propyl-cyclooctanol
  参考文献：
  名称：

  Braude et al., Journal of the Chemical Society, 1957, p. 4711,4718

  摘要：

  DOI：

文献信息

• Immunomodulating Heterocyclic Compounds
  申请人：Matthews Ian Richard

  公开号：US20090312334A1

  公开（公告）日：2009-12-17

  Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy: wherein R 1 and R 3 independently represent H; F; Cl; Br; —NO 2 ; —CN; C 1 -C 6 alkyl optionally substituted by F or Cl; or C 1 -C 6 alkoxy optionally substituted by F; R 4 represents a carboxylic acid group (—COOH) or an ester thereof, or —C(═O)NR 6 R 7 , —NR 7 C(═O)R 6 , —NR 7 C(═O)OR 6 , —NHC(═O)NR 7 R 6 or —NHC(═S)NR 7 R 6 wherein R 6 represents H, or a radical of formula -(Alk) m -Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C 1 -C 12 alkylene, or C 2 -C 12 alkenylene, or C 2 -C 12 alkynylene radical or a divalent C 3 -C 12 carbocyclic radical, any of which radicals may contain one or more —O—, —S— or —N(R 8 )— links wherein R 8 represents H or C 1 -C 4 alkyl, C 3 -C 4 alkenyl, C 3 -C 4 alkynyl, or C 3 -C 6 cycloalkyl, and Q represents H; —NR 9 R 10 wherein R 9 and R 10 independently represents H; C 1 -C 4 alkyl; C 3 -C 4 alkenyl; C 3 -C 4 alkynyl; C 3 -C 6 cycloalkyl; an ester group; an optionally substituted carbocyclic or heterocyclic group; or R 9 and R 10 form a ring when taken together with the nitrogen to which they are attached, which ring is optionally substituted; and R 7 represents H or C 1 -C 6 alkyl; or when taken together with the atom or atoms to which they are attached R 6 and R 7 form an optionally substituted monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula -(Z) n -(Alk)- or -(Alk)-(Z) n - wherein Z represents —O—, —S— or —NH—, Alk is as defined in relation to R 6 and n is 0 or 1.

  公式（I）的化合物是CD80的抑制剂，可用于免疫调节治疗：其中，R1和R3分别表示H; F; Cl; Br; -NO2; -CN; C1-C6烷基，所述烷基可选地被F或Cl取代; 或C1-C6烷氧基，所述烷氧基可选地被F取代; R4表示羧酸基(-COOH)或其酯，或-C（═O）NR6R7，-NR7C（═O）R6，-NR7C（═O）OR6，-NHC（═O）NR7R6或-NHC（═S）NR7R6，其中R6表示H，或式-(Alk)m-Q的基团，其中m为0或1，Alk是可选地取代的二价直链或支链C1-C12烷基，或C2-C12烯基，或C2-C12炔基基团或二价C3-C12环烷基基团，其中任何一个基团可以含有一个或多个-O-，-S-或-N（R8）-键，其中R8表示H或C1-C4烷基，C3-C4烯基，C3-C4炔基或C3-C6环烷基，而Q表示H; -NR9R10，其中R9和R10独立地表示H; C1-C4烷基; C3-C4烯基; C3-C4炔基; C3-C6环烷基; 酯基; 可选地取代的环烷基或杂环基; 或者R9和R10与它们所连接的氮一起形成一个环，该环是可选地取代的; 而R7表示H或C1-C6烷基; 或者当R6和R7与它们所连接的原子或原子一起形成一个可选地取代的含5、6或7个环原子的单环杂环时; 而X表示键或式-(Z)n-(Alk)-或-(Alk)-(Z)n-的二价基团，其中Z表示-O-，-S-或-NH-，Alk如在R6中所定义，n为0或1。
• PROCESS FOR PRODUCING ALDEHYDE COMPOUND OR KETONE COMPOUND WITH USE OF MICROREACTOR
  申请人：Ube Industries, Ltd.

  公开号：EP1710223B1

  公开（公告）日：2012-10-31
• Method for producing aldehyde compound or ketone compound by using microreactor
  申请人：Ataka Kikuo

  公开号：US20070149823A1

  公开（公告）日：2007-06-28

  The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.
• US7332632B2
  申请人：——

  公开号：US7332632B2

  公开（公告）日：2008-02-19
• US8309552B2
  申请人：——

  公开号：US8309552B2

  公开（公告）日：2012-11-13