2,4-di-tert-butyl-6-bromophenyl benzyl ether | 245434-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-di-tert-butyl-6-bromophenyl benzyl ether
• 英文别名: 2-benzyloxy-3,5-di-tert-butylbromobenzene；1-Bromo-3,5-ditert-butyl-2-phenylmethoxybenzene
• CAS: 245434-17-7
• 化学式: C₂₁H₂₇BrO
• 分子量: 375.349
• InChiKey: KDXMSRJGASGPPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-di-tert-butyl-6-bromophenyl benzyl ether 、 ferrocene-1,1'-dithiol 在 1,1'-双(二苯基膦)二茂铁 、 tris-(dibenzylideneacetone)dipalladium(0) 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以54%的产率得到2-benzyloxy-3,5-di-tert-butylphenyl-1,1'-ferrocenyldithiol
  参考文献：
  名称：

  Redox Control of Group 4 Metal Ring-Opening Polymerization Activity toward l-Lactide and ε-Caprolactone

  摘要：

  The activity of several group 4 metal alkoxide complexes supported by ferrocene-based ligands was controlled using redox reagents during the ring-opening polymerization of L-lactide and e-caprolactone. Switching in situ between the oxidized and reduced forms of a metal complex resulted in a change in the corresponding rate of polymerization. Opposite behavior was observed for each monomer used. One-pot copolymerization of the two monomers to give block copolymers was also achieved.

  DOI：

  10.1021/ja505883u
• 作为产物：
  描述：

  2-溴-4,6-二-叔-丁基苯酚 、 溴甲苯 在 potassium carbonate sesquihydrate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以92%的产率得到2,4-di-tert-butyl-6-bromophenyl benzyl ether
  参考文献：
  名称：

  Redox Control of Group 4 Metal Ring-Opening Polymerization Activity toward l-Lactide and ε-Caprolactone

  摘要：

  The activity of several group 4 metal alkoxide complexes supported by ferrocene-based ligands was controlled using redox reagents during the ring-opening polymerization of L-lactide and e-caprolactone. Switching in situ between the oxidized and reduced forms of a metal complex resulted in a change in the corresponding rate of polymerization. Opposite behavior was observed for each monomer used. One-pot copolymerization of the two monomers to give block copolymers was also achieved.

  DOI：

  10.1021/ja505883u

文献信息

• Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
  申请人：Galderma Research & Development, S.N.C.

  公开号：US20040092594A1

  公开（公告）日：2004-05-13

  Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula. (I): 1 in which Ar 1 is a radical having one of the structural formulae (a)-(c): 2 Ar 2 is a radical having one of the following formulae (d)-(h): 3 and X is a radical having one of the following formulae (i)-(l): 4 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

  具有药用/化妆品活性的双环芳香化合物具有结构式（I）：1其中Ar1是具有结构式（a）-（c）之一的基团：2Ar2是具有以下式（d）-（h）之一的基团：3而X是具有以下式（i）-（l）之一的基团：4并且对于治疗各种疾病状态（无论是人类还是兽医），例如皮肤病，风湿病，呼吸系统疾病，心血管疾病和眼科疾病以及哺乳动物皮肤和毛发状况/疾病的治疗非常有用。
• Composés bicycliques-aromatiques et leur utilisation en médecine humaine ou vétérinaire ainsi qu'en cosmétologie
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP0947496A1

  公开（公告）日：1999-10-06

  L'invention concerne de nouveaux composés bicycliques-aromatiques qui présentent comme formule générale (I) : ainsi que l'utilisation de ces derniers dans des compositions pharmaceutiques destinées à un usage en médecine humaine ou vétérinaire (affections dermatologiques, rhumatismales, respiratoires, cardiovasculaires et ophtalmologiques notamment), ou bien encore dans des compositions cosmétiques.

  本发明涉及通式（I）的新型双环芳香族化合物： 以及后者在用于人类或兽医（尤其是皮肤病、风湿病、呼吸道疾病、心血管疾病和眼科疾病）的药物组合物或化妆品组合物中的用途。
• Transition metal complex ligand and olefin polymerization catalyst containing transition metal complex
  申请人：Otomaru Yuka

  公开号：US20070135600A1

  公开（公告）日：2007-06-14

  The invention provides a transition metal complex of formula (3) below: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same or different and each independently represents a hydrogen atom, a halogen atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); R 5 represents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); X 1 represents a hydrogen atom, a halogen atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); L represents a balancing counter ion or neutral ligand similar to X 1 that is bonding or coordinating to metal M; and q represents an integer of 0 or 1, and G 20 represents any one of G 21 to G 26 below: where A 1 represents an element of Group 15 of the periodic table, wherein A 1 in G 23 represents an anion of an element of Group 15 of the periodic table, and A 1 in G 21 represents a nitrogen atom; R 9 , R 14 , R 12 , R 13 , R 19 , R 20 , R 10 , R 11 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 and R 22 each independently represents, a hydrogen atom; or a substituted or unsubstituted alkyl groups having 1 to 10 carbon atom(s), and the line linking M and R 20 represents that M is coordinated or linked to an element of Group 15 or 16 of the periodic table or to a fluorine atom constituting R 20 .
• US6632963B1
  申请人：——

  公开号：US6632963B1

  公开（公告）日：2003-10-14
• US6924388B2
  申请人：——

  公开号：US6924388B2

  公开（公告）日：2005-08-02