Carboxymethyltrimethyl-3H-indole succinimidyl ester | 178822-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Carboxymethyltrimethyl-3H-indole succinimidyl ester
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 2-(2,3,3-trimethylindol-5-yl)acetate
• CAS: 178822-78-1
• 化学式: C₁₇H₁₈N₂O₄
• 分子量: 314.341
• InChiKey: REQITBSTXJRKPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  76
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Carboxymethyltrimethyl-3H-indole succinimidyl ester 在 吡啶 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 17.33h， 生成 2-[3-(1-(5-Carboxypentyl)-5-{[N-(3,4,5-trihydroxy-6-methoxytetrahydropyran-2-ylmethyl)carbamoyl]methyl}-3,3-dimethyl-2,3-dihydro-1H-indol-2-ylidene)propenyl]-1-ethyl-5-{[N-(3,4,5-trihydroxy-6-methoxytetrahydropyran-2-yl-methyl)carbamoyl]methyl}-3,3-d...
  参考文献：
  名称：

  Reddington, Mark V., Journal of the Chemical Society. Perkin transactions I, 1998, # 1, p. 143 - 147

  摘要：

  DOI：
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 2,3,3-trimethyl-3H-indole-5-acetic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Carboxymethyltrimethyl-3H-indole succinimidyl ester
  参考文献：
  名称：

  Reddington, Mark V., Journal of the Chemical Society. Perkin transactions I, 1998, # 1, p. 143 - 147

  摘要：

  DOI：

文献信息

• In-vivo diagnostic method by means of near infrared radiation
  申请人：Institut Fur Diagnostikforschung GmbH An Der Freien Universitat Berlin

  公开号：US20010055567A1

  公开（公告）日：2001-12-27

  This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.

  本发明涉及一种基于近红外辐射（NIR）的体内诊断方法，该方法使用水溶性染料及其生物大分子加合物（每种染料都具有特定的光物理和药物化学特性）作为近红外范围内荧光和透射诊断的对比介质，还涉及含有此类染料的新型染料和药物。
• Near infrared imaging agent
  申请人：Institut fur Diagnostikforschung GMBH an der freien Universita (copy)

  公开号：US20030170179A1

  公开（公告）日：2003-09-11

  This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.

  本发明涉及一种基于近红外辐射（NIR）的体内诊断方法，该方法使用水溶性染料及其生物大分子加合物（每种染料都具有特定的光物理和药物化学特性）作为近红外范围内荧光和透射诊断的对比介质，还涉及含有此类染料的新型染料和药物。
• In-vivo diagnostic method by near infrared radiation
  申请人：Licha Kai

  公开号：US20050106106A1

  公开（公告）日：2005-05-19

  This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
• Near Infrared Imaging Agent
  申请人：Licha Kai

  公开号：US20100129293A1

  公开（公告）日：2010-05-27

  This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
• US6083485A
  申请人：——

  公开号：US6083485A

  公开（公告）日：2000-07-04