2-Methylinosin | 13591-89-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-Methylinosin
• 英文别名: 2-methyl-9-β-D-ribofuranosyl-1,9-dihydro-purin-6-one；2-methylinosine；(2R,3R,4S,5R)-2-(6-Hydroxy-2-methyl-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol；9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methyl-1H-purin-6-one
• CAS: 13591-89-4
• 化学式: C₁₁H₁₄N₄O₅
• 分子量: 282.256
• InChiKey: SOTIPZUHKSPAMN-IOSLPCCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-Methylinosin 在 nucleoside oxidase from S_. maltophilia 作用下， 以 phosphate buffer 为溶剂， 生成 (2S,3S,4R,5R)-3,4-Dihydroxy-5-(2-methyl-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-2-carboxylic acid
  参考文献：
  名称：

  A versatile procedure for the generation of nucleoside 5′-carboxylic acids using nucleoside oxidase

  摘要：

  The nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5'-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00456-6

文献信息

• 2, N.sup.6 -disubstituted adenosines, tri-O-ester derivatives and their
  申请人：Novo Nordisk A/S

  公开号：US05484774A1

  公开（公告）日：1996-01-16

  A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is halogen, trifluoromethyl, cyano, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 -alkylamino or C.sub.1-6 -dialkylamino; R.sup.1 and R.sup.4 are H or straight or branched C.sub.1-6 -alkyl or trifluoromethyl or R.sup.1 and R.sup.4 together form a cycloalkyl ring; Y is O, S, SO.sub.2, NH or N-alkyl; R.sup.5 is selected from optionally substituted heterocycles. R.sup.6 and R.sup.7 are hydrogen, benzoyl or C.sub.1-6 -alkanoyl. The compounds have been found useful for treating central nervous system and cardiovascular ailments.

  化合物的分子式（I），或其药学上可接受的盐：##STR1##其中X是卤素，三氟甲基，氰基，C.sub.1-6-烷氧基，C.sub.1-6-烷硫基，C.sub.1-6-烷基氨基或C.sub.1-6-二烷基胺基；R.sup.1和R.sup.4为H或直链或支链C.sub.1-6-烷基或三氟甲基，或R.sup.1和R.sup.4一起形成环烷基环；Y是O，S，SO.sub.2，NH或N-烷基；R.sup.5从可选择的取代的杂环中选择。R.sup.6和R.sup.7是氢，苯甲酰基或C.sub.1-6-烷酰基。已发现这些化合物对治疗中枢神经系统和心血管疾病有用。
• Rapid diagnostic test for LAMP
  申请人：New England Biolabs, Inc.

  公开号：US11345970B2

  公开（公告）日：2022-05-31

  Kits and methods are described that are directed to specific and sensitive methods of target nucleic acid detection and more specifically detecting target nucleic acids directly from biological samples. The kits and methods were developed to be easy to use involving a minimum number of steps and giving rapid and consistent results either at point of care or in high throughput situations. The kits and methods utilize in various combinations, reversible inhibitors of kit components, thermolabile enzymes, poloxamers, various salts, indicators and one or more Loop-Mediated Isothermal Amplification (LAMP) primer sets for detecting single and/or multiple targets and variants of the targets including SARS-CoV-2 targets and variants thereof in a single reaction. The kits and methods permit detection of the target nucleic with similar sensitivity regardless of the presence of undefined mutations that may enhance the virulence of cells or viruses containing the undefined mutations.

  所述试剂盒和方法用于特异灵敏的靶核酸检测方法，更具体地说是直接从生物样本中检测靶核酸。这些试剂盒和方法易于使用，步骤最少，无论是在医疗点还是在高通量情况下，都能快速、一致地得到结果。这些试剂盒和方法以不同的组合使用试剂盒成分的可逆抑制剂、热稳定酶、多聚酶、各种盐、指示剂和一个或多个环路等温扩增（LAMP）引物组，用于在单次反应中检测单个和/或多个靶标和靶标的变体，包括 SARS-CoV-2 靶标及其变体。这些试剂盒和方法能以类似的灵敏度检测目标核酸，而不管是否存在未定义的突变，这些突变可能会增强含有未定义突变的细胞或病毒的毒性。
• PURINE DERIVATIVES
  申请人：NOVO NORDISK A/S

  公开号：EP0603348A1

  公开（公告）日：1994-06-29
• NOVEL ADENOSINE DERIVATIVES
  申请人：NOVO NORDISK A/S

  公开号：EP0607367A1

  公开（公告）日：1994-07-27
• SELF-AVOIDING MOLECULAR RECOGNITION SYSTEMS IN DNA AMPLIFICATION
  申请人：Benner, Steven A.

  公开号：EP2321332A1

  公开（公告）日：2011-05-18