2-Methyl-3-(5-methylisoxazol-4-yl)-6-methoxypyridine | 459856-13-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-3-(5-methylisoxazol-4-yl)-6-methoxypyridine
• 英文别名: 4-(6-methoxy-2-methylpyridin-3-yl)-5-methyl-1,2-oxazole
• CAS: 459856-13-4
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.22
• InChiKey: WJXKFBYYQJMQKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-(5-methylisoxazol-4-yl)-6-methoxypyridine 生成
  参考文献：
  名称：

  4 - (2-butylamino) - 2, 7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo- [1,5-A] - 1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

  摘要：

  Corticotropin releasing factor (CRF)拮抗剂的化学式(I):1及其在治疗焦虑、抑郁和其他精神、神经系统疾病方面的应用，以及治疗与心理病理障碍和压力相关的免疫、心血管或心脏相关疾病和结肠过敏反应。

  公开号：

  US20030125330A1
• 作为产物：
  描述：

  4-碘-5-甲基异恶唑 、 6-甲氧基-2-甲基吡啶-3-硼酸 在 4-碘-5-甲基异恶唑 作用下， 生成 2-Methyl-3-(5-methylisoxazol-4-yl)-6-methoxypyridine
  参考文献：
  名称：

  4 - (2-butylamino) - 2, 7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo- [1,5-A] - 1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

  摘要：

  Corticotropin releasing factor (CRF)拮抗剂的化学式(I):1及其在治疗焦虑、抑郁和其他精神、神经系统疾病方面的应用，以及治疗与心理病理障碍和压力相关的免疫、心血管或心脏相关疾病和结肠过敏反应。

  公开号：

  US20030125330A1

文献信息

• [EN] 4-(2-BUTYLAMINO)-2,7-DIMETHYL-8-(2-METHYL-6-METHOXYPYRID-3-YL) PYRAZOLO-[1,5-A]-1,3,5-TRIAZINE, ITS ENANTIOMERS AND PHARMACEUTICALLY ACCEPTABLE SALTS AS CORTICOTROPIN RELEASING FACTOR RECEPTOR LIGANDS<br/>[FR] 4-(2-BUTYLAMINO)-2,7-DIMETHYL-8-(2-METHYL-6-METHOXYPYRID-3-YL) PYRAZOLO-[1,5-A]-1,3,5-TRIAZINE, SES ENANTIOMERES ET SELS PHARMACEUTIQUEMENT ACCEPTABLES EN TANT QUE LIGANDS DU RECEPTEUR DE LA CORTICOLIBERINE
  申请人：BRISTOL MYERS SQUIBB PHARMA CO

  公开号：WO2002072202A1

  公开（公告）日：2002-09-19

  Corticotropin releasing factor (CRF) antagonists of Formula (I), and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

  Corticotropin releasing factor (CRF) Formula (I) 的拮抗剂，用于治疗焦虑、抑郁和其他精神、神经障碍，以及治疗免疫、心血管或与心脏相关的疾病和与心理病理扰乱和压力相关的结肠过敏性。
• 4-(2-butylamino)-2, 7-dimethyl-8-(2-methyl-6-methoxypyrid-3-YL) pyrazolo-[1,5-A]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：US07157578B2

  公开（公告）日：2007-01-02

  Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

  Corticotropin releasing factor (CRF)拮抗剂的化学式(I)，以及其在治疗焦虑、抑郁和其他精神、神经性疾病，以及治疗免疫、心血管或与心脏相关的疾病和与心理病理紊乱和压力相关的结肠过敏性方面的应用。
• 4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
  申请人：Gilligan J. Paul

  公开号：US20070054913A1

  公开（公告）日：2007-03-08

  Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

  Corticotropin releasing factor (CRF)拮抗剂的化学式（I）及其在治疗焦虑、抑郁和其他精神、神经系统疾病方面的用途，以及治疗与心理病理障碍和压力相关的免疫、心血管或心脏疾病和结肠过敏反应。
• 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：US07358252B2

  公开（公告）日：2008-04-15

  Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

  Corticotropin releasing factor (CRF) 拮抗剂的化学式 (I) 及其用于治疗焦虑、抑郁和其他精神、神经系统疾病，以及治疗与心理障碍和压力相关的免疫、心血管或心脏相关疾病和结肠过敏性反应。
• 4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-[1,5-A]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：US07662817B2

  公开（公告）日：2010-02-16

  Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

  Corticotropin releasing factor (CRF) Formula (I) 的拮抗剂，可用于治疗焦虑、抑郁和其他精神、神经疾病，以及免疫、心血管或与心脏相关的疾病，以及与心理病理障碍和压力相关的结肠过敏反应的治疗。