(1R,2S)-trans-2-amino-1-(carboxymethyl)cyclopropane hydrochloride | 1449741-43-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1R,2S)-trans-2-amino-1-(carboxymethyl)cyclopropane hydrochloride
• 英文别名: 2-[(1R,2S)-2-aminocyclopropyl]acetic acid;hydrochloride
• CAS: 1449741-43-8
• 化学式: C₅H₉NO₂*ClH
• 分子量: 151.593
• InChiKey: TXHWYCAFUCZXHZ-HJXLNUONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.23
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (1R,2S)-2-(t-butyldiphenylsilyloxy)methyl-1-(2-hydroxyethyl)cyclopropane 在 盐酸 、 叠氮磷酸二苯酯 、 palladium 10% on activated carbon 、 四丁基氟化铵 、 水 、 氢气 、 四丁基碘化铵 、 sodium hydride 、 戴斯-马丁氧化剂 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， -10.0~20.0 ℃ 、101.33 kPa 条件下， 反应 59.83h， 生成 (1R,2S)-trans-2-amino-1-(carboxymethyl)cyclopropane hydrochloride
  参考文献：
  名称：

  Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports

  摘要：

  A series of cyclopropane-based conformationally restricted gamma-aminobutyric acid (GABA) analogs with stereochemical diversity, that is, the trans- and cis-2,3-methano analogs Ia and Ib and their enantiomers ent-Ia and ent-Ib, and also the trans- and cis-3,4-methano analogs IIa and IIb and their enantiomers ent-IIa and ent-Iib, were synthesized from the chiral cyclopropane units Type-a and Type-b that we developed. These analogs were systematically evaluated with four GABA transporter (GAT) subtypes. The trans-3,4-methano analog IIa had inhibitory effects on GAT3 (IC50 = 23.9 mu M) and betaine-GABA transporter1 (5.48 mu M), indicating its potential as an effective lead compound for the development of potent GAT inhibitors due to its hydrophilic and low molecular weight properties and excellent ligand efficiency. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.06.063

文献信息

• Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports
  作者：Kazuaki Nakada、Mamie Yoshikawa、Soichiro Ide、Akihiro Suemasa、Shuhei Kawamura、Takaaki Kobayashi、Eiji Masuda、Yoshihiko Ito、Wataru Hayakawa、Takahiro Katayama、Shizuo Yamada、Mitsuhiro Arisawa、Masabumi Minami、Satoshi Shuto

  DOI：10.1016/j.bmc.2013.06.063

  日期：2013.9

  A series of cyclopropane-based conformationally restricted gamma-aminobutyric acid (GABA) analogs with stereochemical diversity, that is, the trans- and cis-2,3-methano analogs Ia and Ib and their enantiomers ent-Ia and ent-Ib, and also the trans- and cis-3,4-methano analogs IIa and IIb and their enantiomers ent-IIa and ent-Iib, were synthesized from the chiral cyclopropane units Type-a and Type-b that we developed. These analogs were systematically evaluated with four GABA transporter (GAT) subtypes. The trans-3,4-methano analog IIa had inhibitory effects on GAT3 (IC50 = 23.9 mu M) and betaine-GABA transporter1 (5.48 mu M), indicating its potential as an effective lead compound for the development of potent GAT inhibitors due to its hydrophilic and low molecular weight properties and excellent ligand efficiency. (C) 2013 Elsevier Ltd. All rights reserved.