kaempferol 4′-O-(β-D-glucopyranosyl-(1→2)(α-L-rhamnopyranosyl-(1→6))-β-D-glucopyranoside) | 1426341-67-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: kaempferol 4′-O-(β-D-glucopyranosyl-(1→2)(α-L-rhamnopyranosyl-(1→6))-β-D-glucopyranoside)
• 英文别名: evolvoside C；2-[4-[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxyphenyl]-3,5,7-trihydroxychromen-4-one
• CAS: 1426341-67-4
• 化学式: C₃₃H₄₀O₂₀
• 分子量: 756.669
• InChiKey: QUQJMJUDBLDSLV-ZBXXLHPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  53
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  324
• 氢给体数：
  12
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  kaempferol 4′-O-(β-D-glucopyranosyl-(1→2)(α-L-rhamnopyranosyl-(1→6))-β-D-glucopyranoside) 、 乙酸酐 在 吡啶 作用下， 生成 kaempferol 4′-O-(β-D-glucopyranosyl-(1→2)(α-L-rhamnopyranosyl-(1→6))-β-D-glucopyranoside) duodecacetate
  参考文献：
  名称：

  Evolvosides C–E, flavonol-4-O-triglycosides from Evolvulus alsinoides and their anti-stress activity

  摘要：

  Phytochemical investigation of the n-butanol fraction of Evolvulus alsinoides (Linn.) led to the isolation of three new phenolic glycosides, evolvosides C, D and E (1-3) along with six known compounds (4-9). The structures of the compounds were elucidated on the basis of spectroscopic analysis, viz. 1D and 2D NMR experiments, chemical study, and comparison with literature data. Evolvoside C (1) was characterized as kaempferol 4'-O-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside, whereas evolvosides D and E (2-3) were found to be mono and di-O-methyl derivatives of 1. The new compounds (1-3) represent rare triglycoside derivatives of flavonol at C-4'. The isolated compounds (1-6) were screened for acute stress-induced biochemical changes in male Sprague-Dawley rats at a dose of 40 mg/kg body weight. Compounds 1 and 2 displayed anti-stress effects by normalizing hyperglycemia, plasma corticosterone, plasma creatine kinase, and adrenal hypertrophy. Compounds 3 and 6 were also found to be effective in normalizing most of these stress parameters, whereas compounds 4 and 5 were ineffective in normalizing most of these effects. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.12.040