2-Methyl-3-(2-{2-[2-(2-methyl-allyloxy)-ethoxy]-ethoxy}-ethoxy)-propene | 91520-52-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-3-(2-{2-[2-(2-methyl-allyloxy)-ethoxy]-ethoxy}-ethoxy)-propene
• 英文别名: 2,15-Dimethyl-4,7,10,13-tetraoxahexadeca-1,15-diene；2-methyl-3-[2-[2-[2-(2-methylprop-2-enoxy)ethoxy]ethoxy]ethoxy]prop-1-ene
• CAS: 91520-52-4
• 化学式: C₁₄H₂₆O₄
• 分子量: 258.358
• InChiKey: OHECKARXXLDQAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-(2-{2-[2-(2-methyl-allyloxy)-ethoxy]-ethoxy}-ethoxy)-propene 在 N-溴代丁二酰亚胺(NBS) 、 triethylamine tris(hydrogen fluoride) 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以77%的产率得到1-Bromo-3-(2-{2-[2-(3-bromo-2-fluoro-2-methyl-propoxy)-ethoxy]-ethoxy}-ethoxy)-2-fluoro-2-methyl-propane
  参考文献：
  名称：

  Bromofluorination of bis(allyl)polyoxyethylene glycol ethers

  摘要：

  The bromofluorination of bis(allyl)polyoxyethylene glycol ethers has been achieved by action of N-bromosuccinimide/triethylamine trishydrogenfluoride. For the starting 2-methylallyl ethers, the addition reaction is regioselective and only tertiary fluorine adducts were observed. Under the same conditions a mixture of addition and degradation products was observed from the nonbranched bis(allyl) ethers. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00143-8

文献信息

• Synthesis of bis(bromomethyl) dimethyl crown ethers and complexation properties of their derivatives having electron-donating sidearms
  作者：Yohji Nakatsuji、Tsuneharu Mori、Mitsuo Okahara

  DOI：10.1016/s0040-4039(01)81190-4

  日期：1984.1

  Several bis(bromomethyl) dimethyl 15-crown-5, 18-crown-6, and 21-crown-7 were prepared according to two methods without protecting reactive bromo substituents. Cis and trans isomers of la are separated and the structures are inferred by considering the complexation property of their derivatives having electron-donating sidearms toward sodium and potassium cations.

  根据两种方法在不保护反应性溴取代基的情况下制备了几种双（溴甲基）二甲基15-crown-5、18-crown-6和21-crown-7。分离Ia的顺式和反式异构体，并通过考虑其具有对钠和钾阳离子的供电子侧臂的衍生物的络合性质来推断结构。