4-bromo-5-phenyl-5-(N-bromoamino)-1,1,2,2-tetrafluoro-4-penten-3-one | 143674-86-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4-bromo-5-phenyl-5-(N-bromoamino)-1,1,2,2-tetrafluoro-4-penten-3-one
• 英文别名: 1-Penten-3-one, 2-bromo-1-(bromoamino)-4,4,5,5-tetrafluoro-1-phenyl-；2-bromo-1-(bromoamino)-4,4,5,5-tetrafluoro-1-phenylpent-1-en-3-one
• CAS: 143674-86-6
• 化学式: C₁₁H₇Br₂F₄NO
• 分子量: 404.984
• InChiKey: XIVBXKBRJKKXCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-氨基-4,4,5,5-四氟-1-苯基戊-1-烯-3-酮 在 溴 、 potassium carbonate 作用下， 以 正己烷 为溶剂， 以91%的产率得到4-bromo-5-phenyl-5-(N-bromoamino)-1,1,2,2-tetrafluoro-4-penten-3-one
  参考文献：
  名称：

  Bromination of regioisomeric fluorine-containing ?-aminovinyl ketones

  摘要：

  Bromination of beta-aminovinyl ketones (AVK) with geminal arrangement of the fluoroalkyl and amino groups gives N-bromo derivatives. Regioisomeric AVK with the amino groups in the beta-position relative to the fluoroalkyl group undergo bromination under analogous conditions to give a mixture of the alpha-bromo and alpha,N-dibromo derivatives. alpha-Bromo derivatives of AVK disproportionate upon storage.

  DOI：

  10.1007/bf00863092

文献信息

• Bromination of regioisomeric fluorine-containing ?-aminovinyl ketones
  作者：K. I. Pashkevich、V. I. Filyakova、N. S. Karpenko

  DOI：10.1007/bf00863092

  日期：1992.3

  Bromination of beta-aminovinyl ketones (AVK) with geminal arrangement of the fluoroalkyl and amino groups gives N-bromo derivatives. Regioisomeric AVK with the amino groups in the beta-position relative to the fluoroalkyl group undergo bromination under analogous conditions to give a mixture of the alpha-bromo and alpha,N-dibromo derivatives. alpha-Bromo derivatives of AVK disproportionate upon storage.