(22R)-4,5,10-trimethoxy-16-azapentacyclo[12.9.0.02,7.08,13.016,22]tricosa-1(14),2,4,6,8(13),9,11-heptaene | 1217508-59-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (22R)-4,5,10-trimethoxy-16-azapentacyclo[12.9.0.02,7.08,13.016,22]tricosa-1(14),2,4,6,8(13),9,11-heptaene
• CAS: 1217508-59-2
• 化学式: C₂₅H₂₉NO₃
• 分子量: 391.51
• InChiKey: ZAUIBEGWABIVCD-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 (22R)-4,5,10-trimethoxy-16-azapentacyclo[12.9.0.02,7.08,13.016,22]tricosa-1(14),2,4,6,8(13),9,11-heptaene
  参考文献：
  名称：

  Antitumor Agents. 274. A New Synthetic Strategy for E-Ring SAR Study of Antofine and Cryptopleurine Analogues

  摘要：

  A new versatile synthetic methodology for the synthesis of enantiomerically pure natural phenanthroindolizidines and phenanthroquinolizidines has been established and described. Natural products R-antofine and R-cryptopleurine, as well as a novel E-ring expanded analogue 13c (E7), 12-oxo-S-antofine (17), and 12N-methyl-12-aza-S-antofine (18) were synthesized with the new method. This strategy will greatly facilitate future SAR studies on the natural alkaloids with E-ring variations.

  DOI：

  10.1021/ol902819j