N-(((2R,3R,4R,5R)-1-(3-aminopropyl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)methyl)acetamide | 909403-22-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: N-(((2R,3R,4R,5R)-1-(3-aminopropyl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)methyl)acetamide
• 英文别名: N-[[(2R,3R,4R,5R)-1-(3-aminopropyl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]acetamide
• CAS: 909403-22-1
• 化学式: C₁₁H₂₃N₃O₄
• 分子量: 261.321
• InChiKey: VXGXRYYYJFRXMK-GWOFURMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 生成 N-(((2R,3R,4R,5R)-1-(3-aminopropyl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)methyl)acetamide
  参考文献：
  名称：

  WO2007/67515

  摘要：

  公开号：

文献信息

• Selective Glycosidase Inhibitors and Uses Thereof
  申请人：Vocadlo David Jaro

  公开号：US20110301217A1

  公开（公告）日：2011-12-08

  The application relates to an immoalditol compound for selectively inhibiting glycosidases, a prodrug thereof and a pharmaceutical composition comprising the compound or the prodrug The application also relates to the use of the immoalditol compound for treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc Such diseases and disorders include neurodegenerative diseases, tauopathy, cancers, and cardiac disorders
• [EN] SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS SÉLECTIFS DE LA GLYCOSIDASE ET LEURS UTILISATIONS
  申请人：UNIV FRASER SIMON

  公开号：WO2010037207A1

  公开（公告）日：2010-04-08

  The application relates to an immoalditol compound for selectively inhibiting glycosidases, a prodrug thereof and a pharmaceutical composition comprising the compound or the prodrug The application also relates to the use of the immoalditol compound for treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-G1cNAc Such diseases and disorders include neurodegenerative diseases, tauopathy, cancers, and cardiac disorders