5-Methoxyisoxazole-3-carbonyl chloride | 53064-59-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Methoxyisoxazole-3-carbonyl chloride
• 英文别名: 5-methoxy-1,2-oxazole-3-carbonyl chloride
• CAS: 53064-59-8
• 化学式: C₅H₄ClNO₃
• 分子量: 161.54
• InChiKey: YFNWZAZTHKHBEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) 、 5-Methoxyisoxazole-3-carbonyl chloride 生成 N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methylisoxazol-3-yl)carbonyl]piperidin-4-yl}acetamide trifluoroacetate
  参考文献：
  名称：

  MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS

  摘要：

  本发明涉及公式I的大环化合物，或其药学上可接受的盐或季铵盐，其中构成成员在此提供，以及它们的组合物和使用方法，它们是JAK / ALK抑制剂，可用于治疗JAK / ALK相关疾病，包括例如炎症和自身免疫性疾病以及癌症。

  公开号：

  US20090286778A1

文献信息

• MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS
  申请人：Combs Andrew Paul

  公开号：US20090286778A1

  公开（公告）日：2009-11-19

  The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及以下化学式I的大环化合物： 或其药用可接受盐或季铵盐，其中所述成员在此提供，并且它们的组成物和使用方法，这些JAK/ALK抑制剂在治疗JAK/ALK相关疾病中有用，例如炎症和自身免疫性疾病以及癌症。
• US8871753B2
  申请人：——

  公开号：US8871753B2

  公开（公告）日：2014-10-28
• [EN] MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS<br/>[FR] COMPOSÉS MACROCYCLIQUES ET LEUR UTILISATION À TITRE D'INHIBITEURS DE KINASE
  申请人：INCYTE CORP

  公开号：WO2009132202A2

  公开（公告）日：2009-10-29

  The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
• Macrocyclic compounds and their use as kinase inhibitors
  申请人：Combs Andrew Paul

  公开号：US08871753B2

  公开（公告）日：2014-10-28

  The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及公式I的大环化合物，其药学上可接受的盐或季铵盐，其中组成成分在此提供，以及它们的组合物和使用方法，它们是JAK/ALK抑制剂，对于治疗JAK/ALK相关疾病，包括炎症和自身免疫性疾病以及癌症有用。