盐酸水苏碱 | 4136-37-2

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 盐酸水苏碱
• 中文别名: 益母草提取物
• 英文名称: stachydrine hydrochloride
• 英文别名: (S)-2-Carboxy-1,1-dimethylpyrrolidinium chloride；(2S)-1,1-dimethylpyrrolidin-1-ium-2-carboxylic acid;chloride
• CAS: 4136-37-2
• 化学式: C₇H₁₄NO₂*Cl
• 分子量: 179.647
• InChiKey: DUNMULOWUUIQIL-RGMNGODLSA-N

物化性质

• 熔点：
  225°C
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.69
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险类别码：
  R20
• 海关编码：
  29339900,2933990090
• 安全说明：
  S22,S45
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

制备方法与用途

生物活性

Stachydrine hydrochloride 是从益母草中提取的主要活性成分，可用于心血管疾病的研究。它能够抑制 NF-κB 信号通路，并具有抗心肌肥大的作用。

靶点

Target	Value
NF-κB

体外研究

干预实验显示，Stachydrine 显著降低了细胞质中的磷酸化 IκB（ser32）蛋白水平和细胞核中的 NF-κB（p65）蛋白水平 (P<0.05)。使用不同浓度的盐酸水苏碱处理 MCF-7 和 T47D 细胞，在剂量和时间依赖性方面明显抑制了细胞增殖。高浓度的 Stachydrine hydrochloride （500 µM 和 1000 µM）显著增加了这两个细胞系在 G1 期的数量，表明盐酸水苏碱可能引起细胞周期阻滞。

化学性质

白色结晶性粉末，易溶于甲醇和水，来源于益母草。

用途

盐酸水苏碱具有提高冠状动脉和心肌营养性血流量、减少心肌细胞坏死的作用。可用于含量测定、鉴定和药理实验等。此外，它还具备镇咳、祛痰和平喘、兴奋子宫的药理作用。

反应信息

• 作为产物：
  描述：

  L-脯氨酸 、 碘甲烷 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以88%的产率得到盐酸水苏碱
  参考文献：
  名称：

  Synthesis and biological evaluation of cyclic analogs of l-carnitine as potential agents in the treatment of myocardial ischemia

  摘要：

  A series of cyclic rigid analogues of l-carnitine has been synthesized and examined for activity as substrates for the carnitine-acylcarnitine translocase, the enzyme that mediates transport of fatty acids into the mitochondria. Synthetic steps to seven of these analogues are described in this paper. Bioassay of these compounds is conducted in a preparation of isolated heart mitochondria that have been previously loaded with [14C]-l-carnitine. Efflux of radioactivity from the mitochondria is then monitored in the presence of the compound being evaluated in order to assess the amount of enzyme activity initiated. The palmityl ester of l-N,N-dimethyl-trans-2-carboxy-4-hydroxypyrrolidinium chloride elicited a 13.63 and 63.07% efflux of [14C]-l-carnitine at concentrations of 3 and 50 mM, respectively. This represents the first instance in which a nonnaturally occurring analogue of l-carnitine has been shown to undergo transport via this mitochondrial translocase, suggesting the possibility that cyclic carnitine analogues may find utility as agents in the treatment of myocardial ischemia.

  DOI：

  10.1021/jm00155a045

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
  申请人：BIOMATRICA, INC.

  公开号：US20150329849A1

  公开（公告）日：2015-11-19

  Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.

  本文描述了稳定的聚合酶组合物，包括聚合酶和聚合酶稳定剂，例如非离子洗涤剂双性稳定剂或阳离子酯类稳定剂，用于核酸扩增或核酸测序。提供了用于单个稳定液体配方中稳定一个或多个聚合酶的组合物。还公开了制备和使用稳定聚合酶组合物的方法以及包含所提供的稳定聚合酶组合物的核酸扩增和测序试剂盒。
• AROMATIC POLYESTER
  申请人：Muroran Institute of Technology

  公开号：EP2479203A1

  公开（公告）日：2012-07-25

  The present invention provides an aromatic polyester which is substantially free from the occurrence of coloration and retains significantly high transparency even after being thermally processed at high temperature and which has high flowability. The aromatic polyester contains a polyhydric phenol residue and a residue of any one of aromatic polycarboxylic acid, halide thereof, and anhydride thereof, and terminals of the aromatic polyester have a structure represented by the formula -C(O)-R. The aromatic polyester has an end-capping rate of 90% or higher and a weight average molecular weight (Mw) ranging from 3,000 to 1,000,000.

  本发明提供了一种芳香族聚酯，该聚酯基本上不会发生着色，即使在高温热加工后仍能保持明显的高透明度，并且具有高流动性。芳香族聚酯含有多羟基苯酚残留物和芳香族多羧酸、其卤化物和其酸酐中任意一种的残留物，芳香族聚酯的端基具有式 -C(O)-R 所代表的结构。芳香族聚酯的端盖率为 90% 或更高，重量平均分子量（Mw）为 3,000 至 1,000,000 之间。
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：M. Technique Co., Ltd.

  公开号：EP3318543A1

  公开（公告）日：2018-05-09

  The present invention addresses the problem of providing a method for producing an organic compound by a phase transfer catalysis reaction using a forced thin-film microreactor. In the present invention, at least two types of fluid, which are a first fluid and a second fluid are used; the first fluid and the second fluid are not miscible with each other; at least the first fluid thereamong includes one or two items selected from the three items of an organic compound, a reactant, and a phase transfer catalyst; from among the fluids other than the first fluid, at least the second fluid includes at least one item from among the items not selected from the three items; the overall first fluid and second fluid contain all of the three items; and each of the fluids meraged

  本发明要解决的问题是提供一种利用强制薄膜微反应器通过相转移催化反应生产有机化合物的方法。在本发明中，至少使用了两种流体，即第一流体和第二流体；第一流体和第二流体互不相溶；至少第一流体中包括从有机化合物、反应物和相转移催化剂三者中选出的一个或两个项目；在除第一流体以外的流体中，至少第二流体包括从未曾从三者中选出的项目中选出的至少一个项目；第一流体和第二流体总体上包含三者中的所有项目；并且每种流体都合并了
• Methods and compositions for treating infection
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10004701B2

  公开（公告）日：2018-06-26

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。