3,5,8,3',4',5'-hexahydroxyflavone | 90332-28-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,5,8,3',4',5'-hexahydroxyflavone
• 英文别名: 3,5,8-trihydroxy-2-(3,4,5-trihydroxy-phenyl)-chromen-4-one；3,5,8-Trihydroxy-2-(3,4,5-trihydroxy-phenyl)-chromen-4-on；3,3',4',5,5',8-Hexahydroxyflavone；3,5,8-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one
• CAS: 90332-28-8
• 化学式: C₁₅H₁₀O₈
• 分子量: 318.24
• InChiKey: JGTKWAPKKUUANC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  148
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3,5,8,3',4',5'-hexahydroxyflavone 生成 3,5,8-triacetoxy-2-(3,4,5-triacetoxy-phenyl)-chromen-4-one
  参考文献：
  名称：

  Ahluwalia et al., Proceedings - Indian Academy of Sciences, Section A, 1958, # 47, p. 230,232

  摘要：

  DOI：
• 作为产物：
  描述：

  5,8-dihydroxy-3-methoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 在 氢碘酸 、 乙酸酐 作用下， 生成 3,5,8,3',4',5'-hexahydroxyflavone
  参考文献：
  名称：

  Ahluwalia et al., Proceedings - Indian Academy of Sciences, Section A, 1958, # 47, p. 230,232

  摘要：

  DOI：

文献信息

• Compositions for sleeping disorders
  申请人：Chan Chang Hsiao

  公开号：US20050261167A1

  公开（公告）日：2005-11-24

  Provided herein is a composition that contains an effective amount of one or more compounds for treating, preventing, or ameliorating a disorder such as insomnia or another sleeping disorder and using the composition.

  本文提供了一种组合物，其中含有有效量的一种或多种化合物，用于治疗、预防或改善失眠或其他睡眠障碍等疾病，以及使用该组合物。
• COMPOSITIONS FOR SLEEPING DISORDERS
  申请人：Chan Hsiao Chang

  公开号：US20090124627A1

  公开（公告）日：2009-05-14

  Provided herein is a method for treating, preventing, or ameliorating a disorder such as insomnia or another sleeping disorder using a composition that contains an effective amount of one or more compounds.
• HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies
  申请人：University of Iowa Research Foundation

  公开号：US20180209956A1

  公开（公告）日：2018-07-26

  Disclosed are methods, compositions, kits, and systems for identifying small-molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1-deficient, BRCA2-deficient, and/or PALB2-deficient phenotype by administering the identified small-molecule inhibitors to the subject.
• US7935714B2
  申请人：——

  公开号：US7935714B2

  公开（公告）日：2011-05-03
• [EN] HIGH THROUGHPUT SCREENING ASSAY FOR IDENTIFYING INHIBITORS OF RAD52 AND USES OF THE IDENTIFIED INHIBITORS FOR TREATMENT AND/OR PREVENTION OF MALIGNACIES<br/>[FR] ESSAI DE CRIBLAGE À HAUT DÉBIT PERMETTANT D'IDENTIFIER DES INHIBITEURS DE RAD52 ET UTILISATIONS DES INHIBITEURS IDENTIFIÉS POUR LE TRAITEMENT ET/OU LA PRÉVENTION DES MALIGNITÉS
  申请人：UNIV IOWA RES FOUND

  公开号：WO2017015187A1

  公开（公告）日：2017-01-26

  Disclosed are methods, compositions, kits, and systems for identifying small- molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1- deficient, BRCA2 -deficient, and/or PALB2 -deficient phenotype by administering the identified small-molecule inhibitors to the subject.