3-(9-Benzyloxy-2,8,10-trimethoxy-4-oxo-4H-dibenzo[cd,f]indol-5-yl)-propionaldehyde | 497179-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-(9-Benzyloxy-2,8,10-trimethoxy-4-oxo-4H-dibenzo[cd,f]indol-5-yl)-propionaldehyde
• 英文别名: 3-(3,5,14-Trimethoxy-11-oxo-4-phenylmethoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1,3,5,7,9(16),12,14-heptaen-10-yl)propanal
• CAS: 497179-89-2
• 化学式: C₂₈H₂₅NO₆
• 分子量: 471.51
• InChiKey: JYRKESMGGMMCHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  74.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(9-Benzyloxy-2,8,10-trimethoxy-4-oxo-4H-dibenzo[cd,f]indol-5-yl)-propionaldehyde 在 palladium on activated charcoal 、 甲酸铵 、 三乙酰氧基硼氢化钠 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 5-(3-Dimethylamino-propyl)-9-hydroxy-2,8,10-trimethoxy-5H-dibenzo[cd,f]indol-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of aristolactams

  摘要：

  A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00794-1
• 作为产物：
  描述：

  9-Benzyloxy-5-(3,3-diethoxy-propyl)-2,8,10-trimethoxy-5H-dibenzo[cd,f]indol-4-one 在 三氯化铁 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 生成 3-(9-Benzyloxy-2,8,10-trimethoxy-4-oxo-4H-dibenzo[cd,f]indol-5-yl)-propionaldehyde
  参考文献：
  名称：

  Synthesis and biological evaluation of aristolactams

  摘要：

  A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00794-1

文献信息

• Synthesis and biological evaluation of aristolactams
  作者：Axel Couture、Eric Deniau、Pierre Grandclaudon、Hélène Rybalko-Rosen、Stéphane Léonce、Bruno Pfeiffer、Pierre Renard

  DOI：10.1016/s0960-894x(02)00794-1

  日期：2002.12

  A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.