tert-butyl 4-(4-acetylphenyl)-1,4-diazepane-1-carboxylate | 364734-99-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl 4-(4-acetylphenyl)-1,4-diazepane-1-carboxylate
• 英文别名: 4-(4-tert-butoxycarbonylhomopiperazino)acetophenone；4-(4-t-butoxycarbonylhomopiperazino)acetophenone
• CAS: 364734-99-6
• 化学式: C₁₈H₂₆N₂O₃
• mdl: MFCD24391281
• 分子量: 318.416
• InChiKey: PRNBWHJIVQVJJG-UHFFFAOYSA-N

物化性质

• 沸点：
  467.2±40.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(4-acetylphenyl)-1,4-diazepane-1-carboxylate 生成 3-(4-homopiperazinophenyl)-5-((N-methyl-N-(4-tetrahydropyranyl)amino)carbamoylamino)indeno[1,2-c]pyrazol-4-one
  参考文献：
  名称：

  US2002/91127

  摘要：

  公开号：

文献信息

• THIENOPYRIDINE DERIVATIVES
  申请人：Sankyo Company, Limited

  公开号：EP1764367A1

  公开（公告）日：2007-03-21

  The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R1 is H or alkyl, R2 is RaS-, RaO-, RaNH-, Ra(Rb)N- or cyclic amino, and Ra and Rb are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

  本发明提供一种促进成骨的化合物。本发明提供具有以下一般式（I）的化合物 其中R1为H或烷基， R2为RaS-、RaO-、RaNH-、Ra(Rb)N-或环状氨基，且 Ra和Rb为可以被取代的烷基、可以被取代的环烷基等，或其药理学上可接受的盐。
• Indeno [1,2-c]pyrazol-4-ones and their uses
  申请人：——

  公开号：US20010027195A1

  公开（公告）日：2001-10-04

  The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): 1 that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

  本发明涉及合成一种新类别的indeno[1,2-c]pyrazol-4-ones化合物，其化学式为(I):1，这些化合物是一类名为细胞周期依赖性激酶的酶的强效抑制剂，与催化亚基cdk1-9及其调节亚基cyclins A-H有关。本发明还提供了一种新颖的治疗癌症或其他增生性疾病的方法，即通过给予这些化合物中的一种或其药用可接受的盐形式的治疗有效剂量。另外，可以通过给予本发明化合物之一与一种或多种其他已知的抗癌或抗增生剂的治疗有效组合来治疗癌症或其他增生性疾病。
• Indeno [1,2-c] pyrazol-4-ones and their uses
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：US06407103B2

  公开（公告）日：2002-06-18

  The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

  本发明涉及合成一类新的indeno[1,2-c]吡唑-4-酮化合物，化学式为(I)，这些化合物是一类被称为细胞周期素依赖性激酶的酶的有效抑制剂，与催化亚基cdk1-9及其调节亚基cyclins A-H有关。本发明还提供了一种新的治疗癌症或其他增生性疾病的方法，通过给予这些化合物之一或其药用可接受的盐形式的治疗有效剂量。另外，可以通过给予本发明化合物之一与一个或多个其他已知的抗癌或抗增生剂的治疗有效组合来治疗癌症或其他增生性疾病。
• Thienopyridine Derivatives
  申请人：Oizumi Kiyoshi

  公开号：US20070219234A1

  公开（公告）日：2007-09-20

  [Problem to be Solved]The present invention provides a compound promoting osteogenesis. [Solution] The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S—, R a O—, R a NH—, R a (R b )N— or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

  【待解决的问题】本发明提供了一种促进成骨作用的化合物。 【解决方案】本发明提供了一种具有以下通式（I）的化合物，其中R1为H或烷基，R2为RaS—、RaO—、RaNH—、Ra（Rb）N—或环状氨基，而Ra和Rb为可被取代的烷基、可被取代的环烷基等，或其药理学上可接受的盐。
• Semicarbazides and their uses
  申请人：——

  公开号：US20020091127A1

  公开（公告）日：2002-07-11

  The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): 1 that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

  本发明涉及一类新的式（I）茚并lsqb;1,2-c]吡唑-4-酮的合成： 1 是一类称为细胞周期蛋白依赖性激酶（与催化亚基 cdk1-7 及其调节亚基 cyclins A-G 有关）的强效抑制剂。 本发明还提供了一种治疗癌症或其他增殖性疾病的新方法，即施用治疗有效量的这些化合物之一或其药学上可接受的盐形式。或者，也可以通过施用本发明的一种化合物与一种或多种其它已知的抗癌或抗增生剂的治疗有效组合物来治疗癌症或其它增生性疾病。