(R)-(1-amino-2,3-dihydro-1H-inden-5-yl)methanol | 883998-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (R)-(1-amino-2,3-dihydro-1H-inden-5-yl)methanol
• 英文别名: [(1R)-1-amino-2,3-dihydro-1H-inden-5-yl]methanol
• CAS: 883998-02-5
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: QKVHXHFQHRIWHL-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-(1-amino-2,3-dihydro-1H-inden-5-yl)methanol 在 manganese(IV) oxide 、 silica-supported carbodiimide 、 1-羟基苯并三唑 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 52.0h， 生成 (R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide
  参考文献：
  名称：

  Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity

  摘要：

  We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4-17 nM). At 90 mg/kg s.c., 28 decreased plasma extravasation in two rodent models of inflammation. A novel method to calculate entropy is introduced and ascribed similar to 30% of the gained affinity between "flexible" 4 (K-i = 132 nM) and "rigid" 28 (K-i = 0.77 nM) to decreased conformational entropy.

  DOI：

  10.1021/jm061224g
• 作为产物：
  描述：

  methyl (1S)-1-hydroxy-2,3-dihydro-1H-indene-5-carboxylate 在 lithium aluminium tetrahydride 、 二苯基膦叠氮化物 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 0.08h， 生成 (R)-(1-amino-2,3-dihydro-1H-inden-5-yl)methanol
  参考文献：
  名称：

  Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity

  摘要：

  We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4-17 nM). At 90 mg/kg s.c., 28 decreased plasma extravasation in two rodent models of inflammation. A novel method to calculate entropy is introduced and ascribed similar to 30% of the gained affinity between "flexible" 4 (K-i = 132 nM) and "rigid" 28 (K-i = 0.77 nM) to decreased conformational entropy.

  DOI：

  10.1021/jm061224g

文献信息

• Piperazine derivatives and methods of use
  申请人：Chen J. Jian

  公开号：US20050014749A1

  公开（公告）日：2005-01-20

  Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于治疗疼痛和炎症介导的疾病等方面有效。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的衍生物，以及用于预防和治疗涉及疼痛、炎症等疾病或其他疾病或病况的药物组合物和方法。该发明还涉及制备这类化合物的方法，以及在这类方法中有用的中间体。
• 1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use
  申请人：Askew C. Benny

  公开号：US20060025400A1

  公开（公告）日：2006-02-02

  Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于治疗疼痛和疾病，如炎症介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的衍生物，药物组合物以及用于预防和治疗涉及疼痛、炎症等疾病和其他不适或情况的方法。该发明还涉及制备此类化合物的方法，以及在此类过程中有用的中间体。
• Substituted sulfones and methods of use
  申请人：Askew C. Benny

  公开号：US20060111347A1

  公开（公告）日：2006-05-25

  Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于治疗疼痛和炎症介导的疾病有效。本发明涵盖新颖的化合物、类似物、前药和其药学上可接受的衍生物、制备这些化合物的药物组合物以及预防和治疗涉及疼痛、炎症等疾病和其他不适或病况的方法。本发明还涉及制备这些化合物的过程，以及在这些过程中有用的中间体。
• Derivatives of piperazine and higher homologues thereof for the treatment of inflammation-related disorders
  申请人：Amgen Inc.

  公开号：EP1878728A2

  公开（公告）日：2008-01-16

  Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions thereof. The compounds claimed can be used in methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like.

  所选化合物可有效治疗疼痛和疾病，如炎症介导的疾病。本发明包括新型化合物及其药学上可接受的衍生物、药物组合物。所要求的化合物可用于预防和治疗涉及疼痛、炎症等疾病和其他弊病或病症的方法。
• [EN] SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS<br/>[FR] SULFONES SUBSTITUES ET LEURS METHODES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2006041888A3

  公开（公告）日：2007-09-07