Ethyl 5-bromo-1-(2-hydroxyethyl)pyrazole-4-carboxylate | 1085802-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Ethyl 5-bromo-1-(2-hydroxyethyl)pyrazole-4-carboxylate
• CAS: 1085802-36-3
• 化学式: C₈H₁₁BrN₂O₃
• 分子量: 263.091
• InChiKey: UXGGMBLUZIOALC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-氨基-1-(2-羟乙基)吡唑-4-甲酸乙酯 在 氢溴酸 、 sodium nitrite 、 copper(ll) bromide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.08h， 生成 Ethyl 5-bromo-1-(2-hydroxyethyl)pyrazole-4-carboxylate
  参考文献：
  名称：

  NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP2163543B1

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11SS-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
  申请人：Masuda Koji

  公开号：US20100240659A1

  公开（公告）日：2010-09-23

  Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R 1 is hydrogen or optionally substituted alkyl, R 2 is —OR 5 , —SR 5 , halogen, halogenated alkyl or the like, R 3 is optionally substituted alkyl or the like, R 4 is optionally substituted alkyl or the like, R 5 is optionally substituted alkyl or the like, R 6 is hydrogen or the like, R 7 and R 8 are each independently hydrogen or the like, R 10 and R 11 are each independently hydrogen or the like, R 12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.
• US8383622B2
  申请人：——

  公开号：US8383622B2

  公开（公告）日：2013-02-26