2-(4-methoxy-phenyl)-2H-tetrazole-5-carboxylic acid | 1194509-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-methoxy-phenyl)-2H-tetrazole-5-carboxylic acid
• 英文别名: 2-(4-Methoxyphenyl)tetrazole-5-carboxylic acid
• CAS: 1194509-58-4
• 化学式: C₉H₈N₄O₃
• 分子量: 220.188
• InChiKey: SUJKUDMMZMHERJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-methoxy-phenyl)-2H-tetrazole-5-carboxylic acid 在 草酰氯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

  摘要：

  We report the first application of a photoinduced 1,3-dipolar cycloaddition reaction to 'staple' a peptide dual inhibitor of the p53-Mdm2/Mdmx interactions. A series of stapled peptide inhibitors were efficiently synthesized and showed excellent dual inhibitory activity in ELISA assay. Furthermore, the positively charged, stapled peptides showed enhanced cellular uptake along with modest in vivo activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.004

文献信息

• Stapled Peptides and Method of Synthesis
  申请人：Lin Qing

  公开号：US20100093086A1

  公开（公告）日：2010-04-15

  A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.

  一种制备钉住的多肽的方法。包括螺旋钉住的多肽，根据基于光化学的方法，进行[3+2]环加成反应制备。螺旋钉住的多肽表现出增加的螺旋性、热稳定性和细胞渗透性。
• STAPLED PEPTIDES AND METHOD OF SYNTHESIS
  申请人：The Research Foundation Of State University Of New York

  公开号：EP2334317A2

  公开（公告）日：2011-06-22
• US8586707B2
  申请人：——

  公开号：US8586707B2

  公开（公告）日：2013-11-19
• [EN] STAPLED PEPTIDES AND METHOD OF SYNTHESIS<br/>[FR] PEPTIDES AGRAFÉS ET PROCÉDÉ DE SYNTHÈSE
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2010033617A2

  公开（公告）日：2010-03-25

  A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.