1-(4-methanesulfonyl-phenyl)-3-(2-phenyl-2H-pyrazol-3-yl)-1H-pyridazin-4-one | 1228533-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-methanesulfonyl-phenyl)-3-(2-phenyl-2H-pyrazol-3-yl)-1H-pyridazin-4-one
• 英文别名: 1-[4-(methylsulfonyl)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one；1-(4-methylsulfonylphenyl)-3-(2-phenylpyrazol-3-yl)pyridazin-4-one
• CAS: 1228533-75-2
• 化学式: C₂₀H₁₆N₄O₃S
• 分子量: 392.438
• InChiKey: VZELKUHJWJVMTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  93
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-((E)-3-dimethylamino-acryloyl)-1-(4-methansulfonyl-phenyl)-1H-pyridazin-4-one 、 苯肼 生成 1-(4-methanesulfonyl-phenyl)-3-(2-phenyl-2H-pyrazol-3-yl)-1H-pyridazin-4-one
  参考文献：
  名称：

  PYRIDAZINONES

  摘要：

  本发明涉及式（I）的新型吡啶二酮化合物，其中R1、R2、R3和R4如所述和所述权利要求中定义，以及其生理上可接受的盐和酯。这些化合物抑制PDE10A，并可用于治疗中枢神经系统疾病。

  公开号：

  US20100152193A1

文献信息

• Pyridazinone compounds
  申请人：Taniguchi Takahiko

  公开号：US20100197651A1

  公开（公告）日：2010-08-05

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ): wherein R 1 represents a substituent, R 2 represents a hydrogen atom, or a substituent, R 3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用并且用作预防或治疗精神分裂症等病症的药物的化合物。该化合物的公式为(I0)：其中，R1代表一个取代基，R2代表一个氢原子或一个取代基，R3代表一个氢原子或一个取代基，环A代表一个可被取代的芳香环，而环B代表一个可被取代的5元杂芳环，或其盐。
• [EN] PYRIDAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRIDAZINONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010063610A1

  公开（公告）日：2010-06-10

  The present invention is concerned with novel pyridazinone derivatives of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as medicaments.

  本发明涉及一种新颖的吡啶并嗪酮衍生物，其化学式为（I），其中R1、R2、R3和R4如描述和权利要求中所定义，并且其生理上可接受的盐和酯。这些化合物抑制PDE10A，可用作药物。
• PYRIDAZINONE COMPOUNDS
  申请人：TANIGUCHI Takahiko

  公开号：US20120277204A1

  公开（公告）日：2012-11-01

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症等药物。化合物的式子为(I0)，其中R1代表取代基；R2代表氢原子或取代基；R3代表氢原子或取代基；环A代表可取代的芳香环，环B代表可取代的五元杂环芳基环或其盐。
• PYRIDAZINONES
  申请人：Alberati Daniela

  公开号：US20100152193A1

  公开（公告）日：2010-06-17

  The present invention is concerned with novel pyridazinones of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of CNS disorders.

  本发明涉及式（I）的新型吡啶二酮化合物，其中R1、R2、R3和R4如所述和所述权利要求中定义，以及其生理上可接受的盐和酯。这些化合物抑制PDE10A，并可用于治疗中枢神经系统疾病。
• 1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound
  申请人：Taniguchi Takahiko

  公开号：US08354411B2

  公开（公告）日：2013-01-15

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症等药物。该化合物的化学式为（I0），其中R1代表取代基；R2代表氢原子或取代基；R3代表氢原子或取代基；环A代表可以被取代的芳香环，环B代表可以被取代的五元杂环芳香环，或其盐。