4-(2-chlorophenoxy)butanesulfonyl chloride | 1202760-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-chlorophenoxy)butanesulfonyl chloride
• 英文别名: 4-(2-Chlorophenoxy)butane-1-sulfonyl chloride
• CAS: 1202760-78-8
• 化学式: C₁₀H₁₂Cl₂O₃S
• 分子量: 283.175
• InChiKey: PCRMJYSINOWKPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-chlorophenoxy)butanesulfonyl chloride 在 氟化铵 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以92%的产率得到4-(2-chlorophenoxy)butanesulfonyl fluoride
  参考文献：
  名称：

  Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

  摘要：

  We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.167
• 作为产物：
  描述：

  Sodium;4-(2-chlorophenoxy)butane-1-sulfonate 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 3.0h， 生成 4-(2-chlorophenoxy)butanesulfonyl chloride
  参考文献：
  名称：

  Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

  摘要：

  We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.167

文献信息

• Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides
  作者：Shakiru O. Alapafuja、Spyros P. Nikas、Vidyanand G. Shukla、Ioannis Papanastasiou、Alexandros Makriyannis

  DOI：10.1016/j.tetlet.2009.09.167

  日期：2009.12

  We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase. (C) 2009 Elsevier Ltd. All rights reserved.