methyl 2-(6-chloro-2,3-dihydro-1H-indol-3-yl)acetate | 929005-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl 2-(6-chloro-2,3-dihydro-1H-indol-3-yl)acetate
• CAS: 929005-86-7
• 化学式: C₁₁H₁₂ClNO₂
• 分子量: 225.675
• InChiKey: DTMRBLHXPKFKFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-(6-chloro-2,3-dihydro-1H-indol-3-yl)acetate 、 N-叔丁氧羰基-4-哌啶酮 在 三乙酰氧基硼氢化钠 、 水 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 Tert-butyl 4-[6-chloro-3-(2-methoxy-2-oxoethyl)-2,3-dihydroindol-1-yl]piperidine-1-carboxylate
  参考文献：
  名称：

  WO2007/29629

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(6-氯-1H-吲哚-3-基)乙酸甲酯 在 盐酸 、 吡啶硼烷 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 乙醚 为溶剂， 反应 1.17h， 以64.4%的产率得到methyl 2-(6-chloro-2,3-dihydro-1H-indol-3-yl)acetate
  参考文献：
  名称：

  WO2007/29629

  摘要：

  公开号：

文献信息

• Indolecarboxylic Acid Derivative Having PGD2 Receptor Antagonistic Activity
  申请人：Kugimiya Akira

  公开号：US20090105274A1

  公开（公告）日：2009-04-23

  The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X 1 =X 2 -X 3 =X 4 - is a formula of —C(R 1 )═C(R 2 )—C(R 3 )═C(R 4 )— etc.; X 5 is C(R 5 ) or N; R 1 , R 2 , R 3 , R 4 and R 5 is independently a hydrogen atom, a halogen atom etc; R 6 is a formula of -Z-R 10 etc. wherein Z is alkylene etc., and R 10 is carboxy etc.; R 7 is optionally substituted alkyloxy etc.; R 8 is independently a halogen atom etc.; R 9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.
• INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
  申请人：KUGIMIYA Akira

  公开号：US20120142687A1

  公开（公告）日：2012-06-07

  The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X 1 ═X 2 —X 3 ═X 4 — is a formula of —C(R 1 )═C(R 2 )—C(R 3 )═C(R 4 )— etc.; X 5 is C(R 5 ) or N; R 1 , R 2 , R 3 , R 4 and R 5 is independently a hydrogen atom, a halogen atom etc; R 6 is a formula of —Z—R 10 etc. wherein Z is alkylene etc., and R 10 is carboxy etc.; R 7 is optionally substituted alkyloxy etc.; R 8 is independently a halogen atom etc.; R 9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.
• US8143285B2
  申请人：——

  公开号：US8143285B2

  公开（公告）日：2012-03-27
• US8623903B2
  申请人：——

  公开号：US8623903B2

  公开（公告）日：2014-01-07
• WO2007/29629
  申请人：——

  公开号：——

  公开（公告）日：——