Tert-butyl 4-[6-chloro-3-(2-methoxy-2-oxoethyl)indol-1-yl]piperidine-1-carboxylate | 929005-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Tert-butyl 4-[6-chloro-3-(2-methoxy-2-oxoethyl)indol-1-yl]piperidine-1-carboxylate
• CAS: 929005-87-8
• 化学式: C₂₁H₂₇ClN₂O₄
• 分子量: 406.909
• InChiKey: OTTVVTMHODNHBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-[6-chloro-3-(2-methoxy-2-oxoethyl)indol-1-yl]piperidine-1-carboxylate 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 反应 2.0h， 以91%的产率得到
  参考文献：
  名称：

  WO2007/29629

  摘要：

  公开号：
• 作为产物：
  描述：

  Tert-butyl 4-[6-chloro-3-(2-methoxy-2-oxoethyl)-2,3-dihydroindol-1-yl]piperidine-1-carboxylate 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以84%的产率得到Tert-butyl 4-[6-chloro-3-(2-methoxy-2-oxoethyl)indol-1-yl]piperidine-1-carboxylate
  参考文献：
  名称：

  WO2007/29629

  摘要：

  公开号：

文献信息

• INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
  申请人：Shionogi Co., Ltd.

  公开号：EP1932839A1

  公开（公告）日：2008-06-18

  The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X1=X2-X3=X4- is a formula of -C(R1)=C(R2)-C(R3)=C(R4)- etc.; X5 is C(R5) or N; R1, R2, R3, R4 and R5 is independently a hydrogen atom, a halogen atom etc; R6 is a formula of -Z-R10 etc. wherein Z is alkylene etc., and R10 is carboxy etc.; R7 is optionally substituted alkyloxy etc.; R8 is independently a halogen atom etc.; R9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了一种具有DP受体拮抗活性的吲哚羧酸衍生物和一种包含上述化合物作为活性成分的药物组合物，并进一步提供了一种治疗过敏性疾病的治疗剂。 通式(I)的化合物： 其中环 A 是芳香碳环等；环 B 是含氮非芳香杂环等；式中 -X1=X2-X3=X4- 是 -C(R1)=C(R2)-C(R3)=C(R4)- 等；X5 是 C(R5) 或 N；R1、R2、R3、R4 和 R5 独立地是氢原子、卤素原子等；R6 是式中 -Z-R10 等，其中 Z 是亚烷基等、R7 是任选取代的烷氧基等；R8 独立地是卤素原子等；R9 独立地是任选取代的烷基等；Y 是单键等；n 是 0 等；q 是 0 等； 药学上可接受的盐或其溶液。
• Indolecarboxylic Acid Derivative Having PGD2 Receptor Antagonistic Activity
  申请人：Kugimiya Akira

  公开号：US20090105274A1

  公开（公告）日：2009-04-23

  The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X 1 =X 2 -X 3 =X 4 - is a formula of —C(R 1 )═C(R 2 )—C(R 3 )═C(R 4 )— etc.; X 5 is C(R 5 ) or N; R 1 , R 2 , R 3 , R 4 and R 5 is independently a hydrogen atom, a halogen atom etc; R 6 is a formula of -Z-R 10 etc. wherein Z is alkylene etc., and R 10 is carboxy etc.; R 7 is optionally substituted alkyloxy etc.; R 8 is independently a halogen atom etc.; R 9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.
• US8143285B2
  申请人：——

  公开号：US8143285B2

  公开（公告）日：2012-03-27
• US8623903B2
  申请人：——

  公开号：US8623903B2

  公开（公告）日：2014-01-07