(2S)-2-hydroxy-N-[4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-yl]-3-methylbutanamide | 935985-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2S)-2-hydroxy-N-[4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-yl]-3-methylbutanamide
• CAS: 935985-58-3
• 化学式: C₁₇H₂₄N₂O₃S
• 分子量: 336.455
• InChiKey: PKYIVSFNHNQGGA-MBIQTGHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S)-2-[tert-butyl(diphenyl)silyl]oxy-N-[4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-yl]-3-methylbutanamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 生成 (2S)-2-hydroxy-N-[4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-yl]-3-methylbutanamide
  参考文献：
  名称：

  EP2151435

  摘要：

  公开号：

文献信息

• AMINODIHYDROTHIAZINE DERIVATIVE
  申请人：Shionogi Co., Ltd.

  公开号：EP1942105B1

  公开（公告）日：2014-04-16
• Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors
  申请人：Shionogi & Co., Ltd.

  公开号：EP2597087B1

  公开（公告）日：2016-03-30
• AMINODIHYDROTHIAZINE DERIVATIVES
  申请人：Kobayashi Naotake

  公开号：US20090082560A1

  公开（公告）日：2009-03-26

  A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R 5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
• PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE
  申请人：Kobayashi Naotake

  公开号：US20100160290A1

  公开（公告）日：2010-06-24

  A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; R 2a , R 2b , R 3a , R 3b , R 4a and R 4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R 5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
• US8173642B2
  申请人：——

  公开号：US8173642B2

  公开（公告）日：2012-05-08