tert-butyl-dimethyl-[(7R,8R)-2-methyl-8-phenylmethoxyoctadecan-7-yl]oxysilane | 1346258-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl-dimethyl-[(7R,8R)-2-methyl-8-phenylmethoxyoctadecan-7-yl]oxysilane
• CAS: 1346258-54-5
• 化学式: C₃₂H₆₀O₂Si
• 分子量: 504.913
• InChiKey: SSYBVVNHBBPNDF-FIRIVFDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.71
• 重原子数：
  35
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tert-butyl-dimethyl-[(7R,8R)-2-methyl-8-phenylmethoxyoctadecan-7-yl]oxysilane 在 吡啶 、 4-二甲氨基吡啶 、 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 9.0h， 生成 (7R,8R)-7-(tert-butyldimethylsilyloxy)-8-(p-toluenesulfonyloxy)-2-methyloctadecane
  参考文献：
  名称：

  An enantiodivergent synthesis of both (+)- and (−)-disparlure from (R)-2,3-cyclohexylideneglyceraldehyde

  摘要：

  Reduction of ketone 3 derived from (R)-2,3-cyclohexylideneglyceraldehyde 1 with some common hydrides took place with syn-selectivity. The resulting major product 4a has been exploited as a common chiral template to prepare both enantiomers 1a,b of disparlure. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.08.013
• 作为产物：
  描述：

  (2R)-1,2-(cyclohexylidenedioxy)tridecan-3-one 在 吡啶 、 咪唑 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 sodium hydride 、 potassium carbonate 、 magnesium 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 mineral oil 为溶剂， 反应 24.25h， 生成 tert-butyl-dimethyl-[(7R,8R)-2-methyl-8-phenylmethoxyoctadecan-7-yl]oxysilane
  参考文献：
  名称：

  An enantiodivergent synthesis of both (+)- and (−)-disparlure from (R)-2,3-cyclohexylideneglyceraldehyde

  摘要：

  Reduction of ketone 3 derived from (R)-2,3-cyclohexylideneglyceraldehyde 1 with some common hydrides took place with syn-selectivity. The resulting major product 4a has been exploited as a common chiral template to prepare both enantiomers 1a,b of disparlure. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.08.013

文献信息

• An enantiodivergent synthesis of both (+)- and (−)-disparlure from (R)-2,3-cyclohexylideneglyceraldehyde
  作者：Akhil Kumar Dubey、Angshuman Chattopadhyay

  DOI：10.1016/j.tetasy.2011.08.013

  日期：2011.7

  Reduction of ketone 3 derived from (R)-2,3-cyclohexylideneglyceraldehyde 1 with some common hydrides took place with syn-selectivity. The resulting major product 4a has been exploited as a common chiral template to prepare both enantiomers 1a,b of disparlure. (C) 2011 Elsevier Ltd. All rights reserved.