5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(2-methyl-2H-tetrazol-5-yl)propan-2-yl)-1H-pyrazole-3-carboxamide | 1265634-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(2-methyl-2H-tetrazol-5-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
• 英文别名: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-[2-(2-methyltetrazol-5-yl)propan-2-yl]pyrazole-3-carboxamide
• CAS: 1265634-00-1
• 化学式: C₂₂H₂₀Cl₃N₇O
• 分子量: 504.806
• InChiKey: ROPKCECBRJJLAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  90.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(2-methyl-2H-tetrazol-5-yl)propan-2-yl)-1H-pyrazole-3-carboxamide 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides

  摘要：

  The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced. In general, a range of modifications were well tolerated. Several molecules with high polar surface area were also indentified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is exemplified with a lead compound from this series. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.055
• 作为产物：
  描述：

  N-(2-(2H-tetrazol-5-yl)propan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 4.0h， 生成 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(2-methyl-2H-tetrazol-5-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
  参考文献：
  名称：

  Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides

  摘要：

  The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced. In general, a range of modifications were well tolerated. Several molecules with high polar surface area were also indentified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is exemplified with a lead compound from this series. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.055

文献信息

• Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides
  作者：Pradip K. Sasmal、D. Srinivasa Reddy、Rashmi Talwar、B. Venkatesham、D. Balasubrahmanyam、M. Kannan、P. Srinivas、K. Shiva Kumar、B. Neelima Devi、Vikram P. Jadhav、Sanjoy K. Khan、Priya Mohan、Hira Chaudhury、Debnath Bhuniya、Javed Iqbal、Ranjan Chakrabarti

  DOI：10.1016/j.bmcl.2010.10.055

  日期：2011.1

  The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced. In general, a range of modifications were well tolerated. Several molecules with high polar surface area were also indentified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is exemplified with a lead compound from this series. (C) 2010 Elsevier Ltd. All rights reserved.