(R)-3-amino-3-(6-methoxypyridin-3-yl)propan-1-ol | 1213193-10-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-3-amino-3-(6-methoxypyridin-3-yl)propan-1-ol
• 英文别名: (3R)-3-amino-3-(6-methoxypyridin-3-yl)propan-1-ol
• CAS: 1213193-10-2
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: PEZVSSIZLRMXLU-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  68.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine 、 (R)-3-amino-3-(6-methoxypyridin-3-yl)propan-1-ol 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 (R)-3-(6-methoxy-pyridin-3-yl)-3-[6-(5-methyl-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-propan-1-ol
  参考文献：
  名称：

  WO2008/123963

  摘要：

  公开号：

文献信息

• Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof
  申请人：Wei Zhi-Liang

  公开号：US08653091B2

  公开（公告）日：2014-02-18

  Fused heterocyclic compounds are provided according to formula 1a or 1b: where R1, R2, and R3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1a或1b提供的融合杂环化合物：其中R1、R2和R3如本文所定义。所提供的化合物及其制药组合物对于哺乳动物，包括人类的预防和治疗各种疾病是有用的，包括但不限于疼痛，炎症，认知障碍，焦虑，抑郁等。
• Amide Compounds, Compositions And Uses Thereof
  申请人：Wei Zhi-Liang

  公开号：US20150266822A1

  公开（公告）日：2015-09-24

  Compounds are provided according to formula 1: where A, B, W, X′, L, R 1 , R 3 , R 4b , and m′ are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  化合物根据公式1提供：其中A、B、W、X'、L、R1、R3、R4b和m'的定义如本文所述。提供的化合物及其制剂在哺乳动物中包括人类的预防和治疗多种病症方面有用，例如但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• PYRID-2YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF
  申请人：Wei Zhi-Liang

  公开号：US20110009432A1

  公开（公告）日：2011-01-13

  Fused heterocyclic compounds are provided according to formula 1a or 1b: where R 1 , R 2 , and R 3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1a或1b定义的熔合杂环化合物：其中R1、R2和R3如本文所定义。所提供的化合物及其制剂在哺乳动物中包括人类的预防和治疗各种病症，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF
  申请人：Evotec AG

  公开号：EP2136639B1

  公开（公告）日：2016-03-09
• US8653091B2
  申请人：——

  公开号：US8653091B2

  公开（公告）日：2014-02-18