2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide | 189156-30-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide
• 英文别名: 2,2-Dichloro-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
• CAS: 189156-30-7
• 化学式: C₄H₄Cl₂N₄O₃S₂
• 分子量: 291.139
• InChiKey: OBQISNFFBVICCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-氨基-1,3,4-噻二唑-2-磺酰胺 、 二氯乙酸酐 以 溶剂黄146 为溶剂， 反应 2.0h， 以74%的产率得到2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide
  参考文献：
  名称：

  Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors

  摘要：

  Three new derivatives of 2-substituted 1,3,4-thiadiazole-5-sulfonamide have been synthesized. These compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide (1); 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide (2); and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide (3). Inhibition effects of these compounds on carbonic anhydrase I and II have been investigated. By comparing I-50 and K-i values of the compounds, it has been found that compound 1 is a more potent inhibitor than acetazolamide (b) on carbonic anhydrase II. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(96)00272-6

文献信息

• Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors
  作者：Oktay Arslan、Ö. Irfan Küfrevioğlu、Barbaros Nalbantoğlu

  DOI：10.1016/s0968-0896(96)00272-6

  日期：1997.3

  Three new derivatives of 2-substituted 1,3,4-thiadiazole-5-sulfonamide have been synthesized. These compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide (1); 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide (2); and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide (3). Inhibition effects of these compounds on carbonic anhydrase I and II have been investigated. By comparing I-50 and K-i values of the compounds, it has been found that compound 1 is a more potent inhibitor than acetazolamide (b) on carbonic anhydrase II. (C) 1997 Elsevier Science Ltd.