(methyl 6-deoxy-α-D-galactopyranosid-6-yl)-(methyl 6'-deoxy-α-D-mannopyranosid-6'-yl) sulfone | 1261294-63-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (methyl 6-deoxy-α-D-galactopyranosid-6-yl)-(methyl 6'-deoxy-α-D-mannopyranosid-6'-yl) sulfone
• 英文别名: (2S,3S,4S,5S,6S)-2-methoxy-6-[[(2S,3R,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methylsulfonylmethyl]oxane-3,4,5-triol
• CAS: 1261294-63-6
• 化学式: C₁₄H₂₆O₁₂S
• 分子量: 418.419
• InChiKey: XPAUCTZKSHWPRS-VBTPRWGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  201
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  (methyl 2,3,4-tri-O-benzyl-6-deoxy-α-D-galactopyranosid-6-yl)-(methyl 2',3',4'-tri-O-benzyl-6'-deoxy-α-D-mannopyranosid-6'-yl) sulfone 在 20% palladium hydroxide on carbon 、 氢气 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 24.0h， 以75%的产率得到(methyl 6-deoxy-α-D-galactopyranosid-6-yl)-(methyl 6'-deoxy-α-D-mannopyranosid-6'-yl) sulfone
  参考文献：
  名称：

  Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase

  摘要：

  Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.09.069

文献信息

• Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase
  作者：Chinmoy Mukherjee、Swatilekha Ghosh、Pinki Nandi、Parimal C. Sen、Anup Kumar Misra

  DOI：10.1016/j.ejmech.2010.09.069

  日期：2010.12

  Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes. (C) 2010 Elsevier Masson SAS. All rights reserved.