[(4R,5E)-7-[(4R,6R)-2,2-dimethyl-6-(4-phenylbutyl)-1,3-dioxan-4-yl]hepta-1,5-dien-4-yl] prop-2-enoate | 1257148-81-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(4R,5E)-7-[(4R,6R)-2,2-dimethyl-6-(4-phenylbutyl)-1,3-dioxan-4-yl]hepta-1,5-dien-4-yl] prop-2-enoate
• CAS: 1257148-81-4
• 化学式: C₂₆H₃₆O₄
• 分子量: 412.569
• InChiKey: BVBXCHDPYHEBOY-STVHBAJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(4R,5E)-7-[(4R,6R)-2,2-dimethyl-6-(4-phenylbutyl)-1,3-dioxan-4-yl]hepta-1,5-dien-4-yl] prop-2-enoate 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成 C₂₃H₃₄O₃
  参考文献：
  名称：

  Concise Total Syntheses of (+)-Strictifolione and (6R)-6-[(4R,6R)-4,6-Dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one

  摘要：

  Concise and efficient asymmetric total syntheses of (+)-strictifolione 1 and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one 2 have been achieved based on the strategic application of one-pot double allylboration and ring-closing metathesis reactions. The total syntheses proceeded in only five and seven steps, respectively, from readily available 3-butenal and represent the shortest syntheses of 1 and 2 reported to date.

  DOI：

  10.1021/jo101875w
• 作为产物：
  描述：

  (4S,5E)-7-[(4R,6R)-2,2-dimethyl-6-(4-phenylbutyl)-1,3-dioxan-4-yl]hepta-1,5-dien-4-ol 、 丙烯酸 在 偶氮二甲酸二异丙酯 、 tetraphenylporphyrin 作用下， 以 苯 为溶剂， 以71%的产率得到[(4R,5E)-7-[(4R,6R)-2,2-dimethyl-6-(4-phenylbutyl)-1,3-dioxan-4-yl]hepta-1,5-dien-4-yl] prop-2-enoate
  参考文献：
  名称：

  Concise Total Syntheses of (+)-Strictifolione and (6R)-6-[(4R,6R)-4,6-Dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one

  摘要：

  Concise and efficient asymmetric total syntheses of (+)-strictifolione 1 and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one 2 have been achieved based on the strategic application of one-pot double allylboration and ring-closing metathesis reactions. The total syntheses proceeded in only five and seven steps, respectively, from readily available 3-butenal and represent the shortest syntheses of 1 and 2 reported to date.

  DOI：

  10.1021/jo101875w

文献信息

• Concise Total Syntheses of (+)-Strictifolione and (6<i>R</i>)-6-[(4<i>R</i>,6<i>R</i>)-4,6-Dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2<i>H</i>-pyran-2-one
  作者：Shibing Tang、Xingang Xie、Xiaolei Wang、Liuer He、Ke Xu、Xuegong She

  DOI：10.1021/jo101875w

  日期：2010.12.3

  Concise and efficient asymmetric total syntheses of (+)-strictifolione 1 and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one 2 have been achieved based on the strategic application of one-pot double allylboration and ring-closing metathesis reactions. The total syntheses proceeded in only five and seven steps, respectively, from readily available 3-butenal and represent the shortest syntheses of 1 and 2 reported to date.