(2-(2-bromoisobutyryloxy)ethyl)phosphonic acid | 1281866-04-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: (2-(2-bromoisobutyryloxy)ethyl)phosphonic acid
• 英文别名: 2-(2-Bromo-2-methylpropanoyl)oxyethylphosphonic acid
• CAS: 1281866-04-3
• 化学式: C₆H₁₂BrO₅P
• 分子量: 275.036
• InChiKey: WWHDMXIUKOXRHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 甲醇 作用下， 反应 12.0h， 生成 (2-(2-bromoisobutyryloxy)ethyl)phosphonic acid
  参考文献：
  名称：

  Recyclable Antibacterial Magnetic Nanoparticles Grafted with Quaternized Poly(2-(dimethylamino)ethyl methacrylate) Brushes

  摘要：

  Highly efficient recyclable antibacterial magnetite nanoparticles consisting of a magnetic Fe3O4 core with an antibacterial poly(quaternary ammonium) (PQA) coating were prepared in an efficient four-step process. The synthetic pathway included: (1) preparation. of Fe3O4 nanoparticles via coprecipitation of Fe2+/Fe3+ in the presence of an alkaline solution; (2) attachment of an ATRP initiating functionality to the surface of the nanoparticles; (3) surface-initiated atom transfer radical polymerization (ATRP) of 2(dimethylamino)ethyl methacrylate (DMAEMA); and (4) transformation of PDMAEMA brushes to PQA via quaternization with ethyl bromide. The success of the surface functionalization was confirmed by FT-IR, thermal gravimetric analysis (TGA), elemental analysis, and transmission electron microscopy (TEM). The PQA-modified magnetite nanoparticles were dispersed in water and exhibited a response to an external magnetic field, making the nanoparticles easy to remove from water after antibacterial tests. The PQA-modified magnetite nanoparticles retained 100% biocidal efficiency against E. coli (10(5) to 10(6) E. coli/mg nanoparticles) during eight exposure/collect/recycle procedures without washing with any solvents or Water.

  DOI：

  10.1021/bm200031v

文献信息

• Double-Layered Plasmonic-Magnetic Vesicles by Self-Assembly of Janus Amphiphilic Gold-Iron(II,III) Oxide Nanoparticles
  作者：Jibin Song、Binghui Wu、Zijian Zhou、Guizhi Zhu、Yijing Liu、Zhen Yang、Lisen Lin、Guocan Yu、Fuwu Zhang、Guofeng Zhang、Hongwei Duan、Galen D. Stucky、Xiaoyuan Chen

  DOI：10.1002/anie.201702572

  日期：2017.7.3

  plasmonic–magnetic vesicle assembled from Janus amphiphilic Au-Fe3O4 NPs grafted with polymer brushes of different hydrophilicity on Au and Fe3O4 surfaces separately. Like liposomes, the vesicle shell is composed of two layers of Au-Fe3O4 NPs in opposite direction, and the orientation of Au or Fe3O4 in the shell can be well controlled by exploiting the amphiphilic property of the two types of polymers

  Janus纳米粒子（JNP）具有独特的功能，包括精确控制的成分分布，表面电荷，偶极矩，模块化和组合功能，这使得其对称对等物无法提供出色的应用。NP的装配具有不同于单个NP的耦合的光学，电子和磁性属性。在此，我们报道了一种新的双层等离激元-磁泡，它们是由两栖的两亲性Au-Fe 3 O 4 NP组装而成的，它们分别在Au和Fe 3 O 4表面上嫁接了具有不同亲水性的聚合物刷。像脂质体一样，囊泡壳由两层Au-Fe 3 O 4组成通过利用两种类型聚合物的两亲特性，可以很好地控制NP的相反方向以及Au或Fe 3 O 4在壳中的取向。
• Grafting of P(OEGA) Onto Magnetic Nanoparticles Using Cu(0) Mediated Polymerization: Comparing Grafting “from” and “to” Approaches in the Search for the Optimal Material Design of Nanoparticle MRI Contrast Agents
  作者：Johan S. Basuki、Lars Esser、Per B. Zetterlund、Michael R. Whittaker、Cyrille Boyer、Thomas P. Davis

  DOI：10.1021/ma401250f

  日期：2013.8.13

  negative contrast agents to enhance MRI efficacy. For optimal effective clinical use in T2/T2* weighted MRI imaging, the aim is to maximize relaxivity (r2) of IONPs, and minimize r1 relaxivity. A prerequisite for successful clinical use of magnetic nanoparticles is colloidal stability in biologically relevant media; biocompatible polymers with antifouling properties such as poly(ethylene glycol) (PEG)

  超顺磁性氧化铁纳米颗粒（IONPs）已被广泛研究为负造影剂，以增强MRI效果。为了在T 2 / T 2 *加权MRI成像中达到最佳的有效临床使用，目的是使IONP的弛豫度（r 2）最大化，并使r 1最小化放松。磁性纳米粒子成功临床应用的前提条件是在生物学相关介质中的胶体稳定性。具有防污性能的生物相容性聚合物（例如聚乙二醇）可以涂在IONP的表面上，以提高稳定性并延长血液循环时间。我们的研究目标是通过实现高接枝密度和胶体稳定性，同时保留IONP磁芯的磁性能，来优化用作造影剂的IONP。为了获得最佳的材料设计，必须精确控制聚合物层的化学功能和链长。在本文中，我们描述了使用“从”接枝方法制备的聚（低聚乙二醇丙烯酸丙烯酸酯）（P（OEGA））功能化的磁性氧化铁纳米颗粒（IONP）的合成。Cu（0）介导的活性自由基聚合（LRP）用于从预官能化IONP的表面生长预定长度的聚合物链。聚合物链通过重复添加