5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfonylmethyl]-pentanoic acid hydroxyamide; hydrochloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfonylmethyl]-pentanoic acid hydroxyamide; hydrochloride
• 英文别名: N-hydroxy-5-phenyl-2-[[4-(pyridine-4-carbonyl)phenyl]sulfonylmethyl]pentanamide;hydrochloride
• 化学式: C₂₄H₂₄N₂O₅S*ClH
• 分子量: 488.992
• InChiKey: YHLIANIUQRLCCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.65
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-Phenyl-2-[[4-(pyridine-4-carbonyl)phenyl]sulfanylmethyl]pentanoic acid 在 Oxone 、 O-(叔丁基二甲基硅烷)羟胺 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 盐酸 作用下， 以 甲醇 、 二氯甲烷 、 乙醚 为溶剂， 生成 2-[4-(1-Oxy-pyridine-4-carbonyl)-benzenesulfonylmethyl]-5-phenyl-pentanoic acid hydroxyamide 、 5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfonylmethyl]-pentanoic acid hydroxyamide; hydrochloride
  参考文献：
  名称：

  Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors

  摘要：

  A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00259-1

文献信息

• Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors
  作者：Andrew D Baxter、Ranjev Bhogal、John Bird、John F Keily、David T Manallack、John G Montana、David A Owen、William R Pitt、Robert J Watson、Ruth E Wills

  DOI：10.1016/s0960-894x(01)00259-1

  日期：2001.6

  A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.