(S)-allyl 2-((S)-1-hydroxybut-3-enyl)-5-((2-methoxyethoxy)methoxy)indoline-1-carboxylate | 1093077-51-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (S)-allyl 2-((S)-1-hydroxybut-3-enyl)-5-((2-methoxyethoxy)methoxy)indoline-1-carboxylate
• 英文别名: prop-2-enyl (2S)-2-[(1S)-1-hydroxybut-3-enyl]-5-(2-methoxyethoxymethoxy)-2,3-dihydroindole-1-carboxylate
• CAS: 1093077-51-0
• 化学式: C₂₀H₂₇NO₆
• 分子量: 377.437
• InChiKey: SHTZZCNGSAGTMN-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-allyl 2-((S)-1-hydroxybut-3-enyl)-5-((2-methoxyethoxy)methoxy)indoline-1-carboxylate 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以83%的产率得到(S)-allyl 2-((S)-1-(tert-butyldimethylsilyloxy)but-3-enyl)-5-((2-methoxyethoxy)methoxy) indoline-1-carboxylate
  参考文献：
  名称：

  Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks

  摘要：

  Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.025
• 作为产物：
  描述：

  (S)-allyl 2-formyl-5-((2-methoxyethoxy)methoxy)indoline-1-carboxylate 、 烯丙基溴化镁 在 zinc(II) chloride 、 氯化铵 作用下， 以 乙醚 、 水 为溶剂， 反应 4.5h， 以47%的产率得到(S)-allyl 2-((R)-1-hydroxybut-3-enyl)-5-((2-methoxyethoxy)methoxy)indoline-1-carboxylate
  参考文献：
  名称：

  Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks

  摘要：

  Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.025

文献信息

• Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks
  作者：Michael Prakesch、Krikor Bijian、Valérie Campagna-Slater、Sophie Quevillon、Reni Joseph、Chang-Qing Wei、Esther Sesmilo、Ayub Reayi、Rajamohan R. Poondra、Michael L. Barnes、Donald M. Leek、Bin Xu、Caroline Lougheed、Matthieu Schapira、Moulay Alaoui-Jamali、Prabhat Arya

  DOI：10.1016/j.bmc.2008.09.025

  日期：2008.11

  Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken. (C) 2008 Elsevier Ltd. All rights reserved.