(7Z,12E)-(3R,5S,9S,14S)-14-Ethyl-5-hydroxy-5-hydroxymethyl-3,9,13-trimethyl-11-methylene-7-methylsulfanyl-oxacyclotetradeca-7,12-diene-2,4-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (7Z,12E)-(3R,5S,9S,14S)-14-Ethyl-5-hydroxy-5-hydroxymethyl-3,9,13-trimethyl-11-methylene-7-methylsulfanyl-oxacyclotetradeca-7,12-diene-2,4-dione
• 英文别名: (3R,5S,7Z,9S,12E,14S)-14-ethyl-5-hydroxy-5-(hydroxymethyl)-3,9,13-trimethyl-11-methylidene-7-methylsulfanyl-1-oxacyclotetradeca-7,12-diene-2,4-dione
• 化学式: C₂₁H₃₂O₅S
• 分子量: 396.548
• InChiKey: LRQSUMUIBKNZKW-MEAVKYDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (E)-(2S,7S)-2,6-Dimethyl-4-methylene-7-(2-trimethylsilanyl-ethoxymethoxy)-non-5-enal 在 吡啶 、 咪唑 、 4-二甲氨基吡啶 、 potassium tert-butylate 、 碘 、 二异丁基氢化铝 、 四乙基氟化铵水合物 、 溶剂黄146 、 甲基磺酰氯 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 、 三苯基膦 、 lithium hexamethyldisilazane 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 (7Z,12E)-(3R,5S,9S,14S)-14-Ethyl-5-hydroxy-5-hydroxymethyl-3,9,13-trimethyl-11-methylene-7-methylsulfanyl-oxacyclotetradeca-7,12-diene-2,4-dione
  参考文献：
  名称：

  Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities

  摘要：

  A series of novel galbonolide derivatives having a modified methyl enol ether moiety were prepared in total synthetic procedures and evaluated for their in vitro antifungal activities. The antifungal activity was labile to modification of the enol ether functionality and almost all of the modified compounds lacked the activity except for the analogue with an introduction of a methylthio group at the C-6 position, which retained a modest antifungal potency against Cryptococcus neoformans. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.09.072

文献信息

• Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities
  作者：Hiroki Sakoh、Yuichi Sugimoto、Hideaki Imamura、Shunji Sakuraba、Hideki Jona、Rie Bamba-Nagano、Koji Yamada、Terutaka Hashizume、Hajime Morishima

  DOI：10.1016/j.bmcl.2003.09.072

  日期：2004.1

  A series of novel galbonolide derivatives having a modified methyl enol ether moiety were prepared in total synthetic procedures and evaluated for their in vitro antifungal activities. The antifungal activity was labile to modification of the enol ether functionality and almost all of the modified compounds lacked the activity except for the analogue with an introduction of a methylthio group at the C-6 position, which retained a modest antifungal potency against Cryptococcus neoformans. (C) 2003 Elsevier Ltd. All rights reserved.