V-28-3B methyl ester | 134002-39-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: V-28-3B methyl ester
• 英文别名: methyl (19E,21E,23E,25E,27E,29E,31E)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-1,3,5,7,9,13,37-heptahydroxy-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
• CAS: 134002-39-4
• 化学式: C₅₉H₈₆N₂O₁₉
• 分子量: 1127.3
• InChiKey: GIDIUOCSTCGLRW-QJSPMWJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  80
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  369
• 氢给体数：
  12
• 氢受体数：
  21

反应信息

• 作为产物：
  描述：

  Mepartricin A 、 mastoparan-A 、 Leu-Lys-Leu-Lys-Ser-Ile-Val-Ser-Trp-Ala-Lys-Lys-Val-Leu-NH2 反应 0.17h， 生成 V-28-3B methyl ester
  参考文献：
  名称：

  Liposome-incorporated mepartricin

  摘要：

  本发明涉及一种用于治疗动物体内播散性真菌感染的脂质体制剂。该脂质体制剂包含聚烯醇类抗真菌化合物美帕曲星。美帕曲星被封装在脂质体内。其中包含美帕曲星的脂质体最好是一个稳定的多层脂质体。脂质体广泛包括一种或多种脂质，其中一种或多种是磷脂单甘油酸，磷酸和鞘脂。脂质最好是磷脂酰胆碱，磷脂酰丝氨酸，磷脂酰甘油，鞘磷脂或磷酸。脂质最好是二肉豆蔻酸磷酸胆碱，二肉豆蔻酸磷酸甘油酯，磷脂酰胆碱和磷脂酰甘油。本发明的脂质体可以包含甾醇，最好是胆固醇。本发明的一个重要方面涉及一种治疗动物体内播散性真菌感染的方法。该方法包括向患有播散性真菌感染的动物体内注射封装有美帕曲星的脂质体的杀真菌有效量。所述脂质体的组成如上所述。在大多数情况下，注射是首选的，但如果特定的真菌菌落因此更直接地到达，则可以口服或局部使用。当动物是患有播散性真菌感染的人时，这种治疗方法最为有用。治疗方法涉及脂质体中包含的杀真菌有效量的美帕曲星，其范围在每千克体重1毫克美帕曲星到每千克体重6毫克美帕曲星之间。

  公开号：

  US04981690A1

文献信息

• Partricin derivatives
  申请人：SPA SOCIETA' PRODOTTI ANTIBIOTICI S.p.A.

  公开号：EP0489308B1

  公开（公告）日：1998-09-02
• Pharmacologic Method Of Lowering Cholesterol Production
  申请人：Lange Yvonne

  公开号：US20070274917A1

  公开（公告）日：2007-11-29

  The present invention provides a screening method for identifying test agents that modulate cell membrane cholesterol activity. The modulating activity of the test agents may be measured using lytic compounds, which cause cell lysis or increases in cell permeability in response to cell membrane cholesterol levels. The invention further provides therapeutic agents that are identified using the screening method. The therapeutic agents either increase or decrease the cell membrane cholesterol activity, cholesterol concentration and/or both in vivo and/or in vitro.
• Endophytic Fungi from Pteromischum Sp. Plant, Compounds and Methods of Use
  申请人：Strobel Gary A.

  公开号：US20100266641A1

  公开（公告）日：2010-10-21

  The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.
• PHARMACOLOGIC METHOD OF LOWERING CHOLESTEROL PRODUCTION
  申请人：LANG Yvonne

  公开号：US20120322091A1

  公开（公告）日：2012-12-20

  The present invention provides a screening method for identifying test agents that modulate cell membrane cholesterol activity. The modulating activity of the test agents may be measured using lytic compounds, which cause cell lysis or increases in cell permeability in response to cell membrane cholesterol levels. The invention further provides therapeutic agents that are identified using the screening method. The therapeutic agents either increase or decrease the cell membrane cholesterol activity, cholesterol concentration and/or both in vivo and/or in vitro.
• Endophytic Fungi from Pteromischum SP. Plant, Compounds and Methods of Use
  申请人：Strobel Gary A.

  公开号：US20130177596A1

  公开（公告）日：2013-07-11

  The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.