ceftazidime monosodium salt | 73547-61-2

• 物质功能分类: 原料药 - 抗生素类药物 - 头孢菌素类药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: ceftazidime monosodium salt
• 英文别名: sodium ceftazidime；ceftazidime sodium；ceftazidime sodium salt；sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxylatopropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 73547-61-2
• 化学式: C₂₂H₂₁N₆O₇S₂*Na
• 分子量: 568.567
• InChiKey: JEEWDSDYUSEQML-ROMZVAKDSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.63
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  248
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  水 、 ceftazidime monosodium salt 、 cadmium(II) chloride 以 水 为溶剂， 以73%的产率得到dichloroaqua(ceftazidimato-κ2-N(5),O(4'))dicadmium(II) monohydrate
  参考文献：
  名称：

  SPECTRAL, THERMAL, AND PHOTOCHEMICAL STUDIES ON CERTAIN FIRST, SECOND, AND THIRD GENERATION CEPHALOSPORIN ANTIBIOTICS AND THEIR CD(II) COMPLEXES

  摘要：

  The reactions of six cephalosporin antibiotics with cadmium chloride afforded the corresponding Cd(H) complexes. The antibiotics are: cephalexin, cephapirin, cefamandole, cefuroxime, cefotaxime, and ceftazidime. Their Cd(11) complexes are of the general formulas Cd(ATB)Cl(.)xH(2)O, Cd(ATB)(2),xH(2)O and Cd-2(ATB)Cl(2)(.)xH(2)O where ATB = the respective antibiotic, x = 1-3. The complexes have been characterized on the basis of elemental analyses, IR, electronic and H-1 NMR spectroscopy, thermal decomposition and photochemical behaviour. Thermogravimetry and derivative thermogravimetry (TG-DTG) have been used to study the stabilities and the thermal decomposition processes of the antibiotics and their Cd(II) complexes. In some cases, the decomposition steps could be correlated with the proper decomposition products, where possible activation energies and order of the decomposition reaction have been calculated from the thermal data. The photochemical behaviour of the antibiotics under investigation and their Cd(II) complexes have been studied. Cephalexin and cefamandole show similar behaviour upon irradiation with light of 298 nm, i.e., an appearance of a new band at long wavelength attributable to the formation of a photocyclization product.The Cd(II) complex of cephalexin exhibits high light sensitivity. Mechanisms of the photolysis of the free antibiotics and Cd-complexes are suggested.

  DOI：

  10.1081/sim-120004445

文献信息

• PREPARATIONS FOR COATING WOUND
  申请人：SSP Co., Ltd.

  公开号：EP1317933A1

  公开（公告）日：2003-06-11

  Provided is an aqueous gel preparation for covering wounds which contains a paste having a gel strength, in water, of 7.5 to 100 g. Such a wound covering preparation is effective for promoting wound healing, is capable of absorbing exudate sufficiently, does not adhere to the wound surface and can be held at the affected part stably.

  本发明提供了一种用于覆盖伤口的水性凝胶制剂，它含有一种在水中凝胶强度为 7.5 至 100 克的糊状物。这种伤口覆盖制剂可有效促进伤口愈合，能够充分吸收渗出物，不会粘附在伤口表面，并能稳定地固定在患处。
• Methods and systems of delivering medication via inhalation
  申请人：Next Safety, Inc.

  公开号：EP1911481A2

  公开（公告）日：2008-04-16

  Systems and methods for delivery of a drug to the respiratory system of a patient where the drug is supplied at a positive pressure relative to atmospheric pressure are provided. In particular, the drugs are delivered to the respiratory system of a patient who is capable of unassisted breathing. With the systems and methods of the present disclosure, medication available in a variety of forms is introduced in a controlled fashion into the air stream in aerosol, nebulized, or vaporized form.

  提供了向病人的呼吸系统输送药物的系统和方法，其中药物是在相对于大气压的正压下提供的。特别是，将药物输送到能够进行无助呼吸的患者的呼吸系统。利用本公开的系统和方法，可将各种形式的药物以气溶胶、雾化或汽化的形式有控制地引入气流中。
• Use of gelsolin to treat infections
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：EP2335722A2

  公开（公告）日：2011-06-22

  The invention relates to the use of plasma gelsolin to treat infections and to monitor the treatment of infections.

  本发明涉及使用血浆凝胶素治疗感染和监测感染治疗。
• COMPOSITION FOR TREATING CARBAPENEM-RESISTANT ANTIBIOTIC ACINETOBACTER BAUMANNII INFECTION
  申请人：Guangzhou Century Clinical Research Co., Ltd

  公开号：EP3919059A1

  公开（公告）日：2021-12-08

  The application of a sulbactam and ceftazidime composition in the preparation of a drug for treating a carbapenem-resistant antibiotic Acinetobacter baumannii infection, characterized in the following: by mass, the amount of ceftazidime used in the sulbactam and ceftazidime composition comprising 10% to 90% of the amount of sulbactam used.

  舒巴坦和头孢他啶组合物在制备治疗耐碳青霉烯类抗生素鲍曼不动杆菌感染药物中的应用，其特征在于：按质量计，舒巴坦和头孢他啶组合物中头孢他啶的用量占舒巴坦用量的10%至90%。
• SS-LACTAM ANTIBIOTIC WITH SIGNIFICANT ACTIVITY AGAINST CANCER E.G. COLON MALIGNANCIES
  申请人：Universität Regensburg

  公开号：EP4108244A1

  公开（公告）日：2022-12-28

  The present invention relates to a cephalosporin for use in a method of preventing and/or treating colon cancer, wherein the cephalosporin comprises a nitrogen, preferably positively charged nitrogen, and a first carboxyl group, preferably a negatively charged carboxyl group; wherein the nitrogen and the carboxyl group of said cephalosporin are spaced apart by three carbon atoms. Furthermore, the present invention relates to a pharmaceutical composition for use in a method of preventing and/or treating colon cancer, wherein said composition comprises a cephalosporin and a pharmaceutically acceptable excipient.

  本发明涉及一种用于预防和/或治疗结肠癌方法的头孢菌素，其中所述头孢菌素包括氮（优选带正电荷的氮）和第一羧基（优选带负电荷的羧基）；其中所述头孢菌素的氮和羧基间隔三个碳原子。此外，本发明涉及一种用于预防和/或治疗结肠癌方法的药物组合物，其中所述组合物包括头孢菌素和药学上可接受的赋形剂。