毒理性
◉ 母乳喂养期间使用总结：尽管没有关于母乳喂养期间使用美罗培南的信息，但乳汁中的水平似乎较低，且通常不期望β-内酰胺类抗生素对哺乳婴儿产生不良反应。偶尔会有报道β-内酰胺类抗生素破坏婴儿的胃肠道菌群，导致腹泻或鹅口疮，但这些影响尚未得到充分评估。瓦博巴坦（vaborbactam）与美罗培南联合使用于Vabomere产品中，在哺乳期母亲中尚未进行研究，但预计该组合与单独使用美罗培南具有类似的担忧。
◉ 对哺乳婴儿的影响：一位母亲在纯母乳喂养新生儿的同时，每8小时接受1克美罗培南静脉注射，持续7天。后来在接受询问时，她表示在她接受美罗培南治疗后的一个月内，她的婴儿没有出现鹅口疮、水样腹泻或需要抗真菌治疗的尿布皮炎。
一名婴儿在产后第4个月前一直被母乳喂养（喂养程度未说明）。在2个月大时，他的母亲因囊性纤维化恶化接受了为期2周的妥布霉素和美罗培南（剂量未指定）治疗。在母亲治疗期间，婴儿的大便模式没有变化，且在6个月大时肾功能正常。
◉ 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:Although no information is available on the use of meropenem during breastfeeding, milk levels appear to be low and beta-lactams are generally not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with beta-lactams, but these effects have not been adequately evaluated. Vaborbactam, which is available in combination with meropenem in the product Vabomere, has not been studied in nursing mothers, but the combination is expected to have similar concerns as with meropenem alone.
◉ Effects in Breastfed Infants:A mother received meropenem 1 gram IV every 8 hours for 7 days while exclusively breastfeeding her newborn. When questioned later, she stated that her infant had no oral thrush, watery diarrhea, or diaper dermatitis that required antifungal therapy during the month following her meropenem therapy.
An infant was breastfed (extent not stated) until the 4th month postpartum. At 2 months of age, his mother was given a 2-week course of tobramycin and meropenem (dosage not specified) for a cystic fibrosis exacerbation. The infant displayed no change in stool pattern during the maternal treatment and had normal renal function at 6 months of age.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
