2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-ylpalmitate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-ylpalmitate
• 英文别名: 3-palmitate quercetin；[2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl] hexadecanoate
• 化学式: C₃₁H₄₀O₈
• 分子量: 540.654
• InChiKey: PACQROQMDAKHJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  39
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  槲皮素 在 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 15.5h， 生成 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-ylpalmitate
  参考文献：
  名称：

  一种槲皮万寿菊素的酯化方法

  摘要：

  本发明提供一种槲皮万寿菊素的酯化方法。所述酯化反应以槲皮万寿菊素为起始原料，经选择性羟基保护反应、酰化反应、选择性羟基脱保护反应制得3‑酯基槲皮万寿菊素；其中，所述选择性羟基保护反应所采用的羟基保护剂为二氯二苯甲烷。本发明方法能够定点在槲皮万寿菊素的3位羟基引入酯键，具有选择性高，目标产物收率高的优点。本发明方法操作简单，成本低，适用于工业化生产应用。

  公开号：

  CN113845504A

文献信息

• Flavonoid Compounds and Uses Thereof
  申请人：Jarrott Bevyn

  公开号：US20090130051A1

  公开（公告）日：2009-05-21

  Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.

  本发明描述了具有抗氧化活性的新型黄酮类化合物。这些化合物和组合物已被证明具有抗氧化性质，特别适用于缺血和再灌注损伤的治疗。本发明还描述了一种化学合成这种黄酮类化合物并测试其功效的方法。这些化合物及其对应的药学上可接受的衍生物和/或盐在制药、保健品和兽医应用领域中有用。
• Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
  申请人：——

  公开号：US20030232091A1

  公开（公告）日：2003-12-18

  The present invention relates to a controlled release system useful to stabilize retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. More specifically, the present invention pertains to stabilized retinol in a solid hydrophobic particle that sustains the release of retinol during the product shelf life and enables a gradual and prolonged release of effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients into biological surfaces. The present invention also refers to a process of stabilizing retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. The invention further relates to cosmetic, dermatological, and pharmaceutical products comprising stable retinol in a hydrophobic particle that can deliver effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients to biological surfaces over an extended period of time.

  本发明涉及一种控释系统，用于稳定化妆品、皮肤病学和药物组合物中的视黄醇、视黄醇衍生物和含有视黄醇的提取物。更具体地说，本发明涉及在固体疏水性颗粒中稳定视黄醇，该颗粒可在产品保质期内维持视黄醇的释放，并使有效水平的视黄醇和其他化妆品、皮肤病学和药物活性成分逐渐并长时间地释放到生物表面。本发明还涉及一种稳定化妆品、皮肤病学和药物组合物中的视黄醇、视黄醇衍生物和含有视黄醇的提取物的工艺。本发明还涉及在疏水性颗粒中含有稳定视黄醇的化妆品、皮肤病学和药物产品，该疏水性颗粒可在较长时间内将有效水平的视黄醇和其他化妆品、皮肤病学和药物活性成分输送到生物表面。
• [EN] MEDICAL COMPOUNDS<br/>[FR] COMPOSÉS MÉDICAUX
  申请人：VERA SALUS RICERCA S R L

  公开号：WO2019008537A9

  公开（公告）日：2020-02-20
• Antimicrobial and Anti-Lipase Activity of Quercetin and its C2-C16 3-O-Acyl-Esters
  作者：Maria Teresa Gatto、Serena Falcocchio、Eleonora Grippa、Gabriela Mazzanti、Lucia Battinelli、Giovanni Nicolosi、Daniela Lambusta、Luciano Saso

  DOI：10.1016/s0968-0896(01)00275-9

  日期：2002.2

  Neither quercetin (Q). nor 3-Ow-acylquercetines, up to 100 mug/mL, had any significant activity on selected gram-positive strains (Staphylococcus aureus, Bacillus subtilis, Listeria ivanovi, Listeria monocytogenes, Listeria serligeri), gram-negative strains (Escherichia coli, Shigella flexneri, Shigella sonnei, Salmonella enteritidis, Salmonella tiphymurium) and yeasts (Candida albicans and Candida glabrata). In addition, we confirmed the known anti-HIV activity of Q (80% inhibition at 40 muM), which might depend on the free hydroxyl in the C-3 position, as suggested by the lack of activity of the 3-O-acylquercetines. Finally, we described an interesting inhibitory activity on Candida rugosa lipase by Q (IC16 = 10(-4) M) and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms. In particular, 3-O-acyl-quercetines, being more active (IC16 = 10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae, and deserve to be studied further. (C) 2001 Elsevier Science Ltd. All rights reserved.
• BIOCATALYTIC PROCESS FOR THE PREPARATION OF 3-0-ACYL-FLAVONOIDS
  申请人：CONSIGLIO NAZIONALE DELLE RICERCHE

  公开号：EP1088094A1

  公开（公告）日：2001-04-04