A-500359A | 254449-20-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: A-500359A
• 英文别名: (2S,3S,4S)-2-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxoethoxy]-3,4-dihydroxy-N-[(3S,7R)-7-methyl-2-oxoazepan-3-yl]-3,4-dihydro-2H-pyran-6-carboxamide
• CAS: 254449-20-2
• 化学式: C₂₄H₃₃N₅O₁₂
• 分子量: 583.552
• InChiKey: RVEJXOKUHHMFKS-BPJITGRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  248
• 氢给体数：
  7
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  A-500359A 在 Amberlyst 15 (H⁺) 、 水 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 、 乙腈 为溶剂， 生成 (3aS,4S,7aS)-4-[(1R)-2-amino-1-[(2S,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hexoxy-3-methoxyoxolan-2-yl]-2-oxoethoxy]-2,2-dimethyl-N-[(3S,7R)-7-methyl-2-oxoazepan-3-yl]-4,7a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyran-6-carboxamide
  参考文献：
  名称：

  Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds

  摘要：

  Acylated derivatives of capuramycin and A-500359A were synthesized and tested for antimycobacterial activity. Compound 20 having a decanoyl group showed very potent activity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00597-3

文献信息

• [EN] COMPOSITIONS AND METHODS COMPRISING CAPURAMYCIN ANALOGUES<br/>[FR] COMPOSITIONS ET PROCÉDÉS COMPRENANT DES ANALOGUES DE LA CAPURAMYCINE
  申请人：SEQUELLA INC

  公开号：WO2009136965A1

  公开（公告）日：2009-11-12

  Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis are provided. In particular, methods and compositions comprising substituted derivatives of capuramycin analogs for the treatment of infectious diseases are provided. Also provided are capuramycin analogue formulations comprising PEGylated compounds, including a PEGylated vitamin E derivative, liposomes and nanoparticle carriers. The invention provides methods and compositions comprising a capuramycin analogue and capuramycin analogues in combination with one or more other active agents.

  提供了治疗由传染性病原体引起的疾病的方法和组合物，特别是结核病。具体而言，提供了包括替代卡普拉霉素类似物的衍生物的方法和组合物，用于治疗传染性疾病。还提供了包括PEG化化合物，包括PEG化维生素E衍生物、脂质体和纳米粒载体的卡普拉霉素类似物配方。本发明提供了包括卡普拉霉素类似物和卡普拉霉素类似物与一个或多个其他活性剂的组合物的方法和组合物。
• COMPOSITIONS AND METHODS COMPRISING CAPURAMYCIN ANALOGUES
  申请人：Reddy Venkata

  公开号：US20090281054A1

  公开（公告）日：2009-11-12

  Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis are provided. In particular, methods and compositions comprising substituted derivatives of capuramycin analogs for the treatment of infectious diseases are provided. Also provided are capuramycin analogue formulations comprising PEGylated compounds, including a PEGylated vitamin E derivative, liposomes and nanoparticle carriers. The invention provides methods and compositions comprising a capuramycin analogue and capuramycin analogues in combination with one or more other active agents.

  提供了治疗由感染性病原体引起的疾病的方法和组合物，特别是结核病。具体提供了包含替代的卡普拉霉素类似物衍生物的方法和组合物，用于治疗传染病。还提供了包括PEG化化合物（包括PEG化维生素E衍生物）、脂质体和纳米粒载体的卡普拉霉素类似物制剂。本发明提供了包括卡普拉霉素类似物和卡普拉霉素类似物与一个或多个其他活性剂的组合物和方法。
• Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds
  作者：Hitoshi Hotoda、Makiko Daigo、Miyuki Furukawa、Kazuhiro Murayama、Chikako Akiyama Hasegawa、Masakatsu Kaneko、Yasunori Muramatsu、Michiko Miyazawa Ishii、Shun-ichi Miyakoshi、Toshio Takatsu、Masatoshi Inukai、Masayo Kakuta、Tomomi Abe、Takashi Fukuoka、Yukio Utsui、Satoshi Ohya

  DOI：10.1016/s0960-894x(03)00597-3

  日期：2003.9

  Acylated derivatives of capuramycin and A-500359A were synthesized and tested for antimycobacterial activity. Compound 20 having a decanoyl group showed very potent activity. (C) 2003 Elsevier Ltd. All rights reserved.